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. 2023 May;86(5):537-539.
doi: 10.1016/j.jinf.2022.11.026. Epub 2022 Dec 1.

Viral dynamics during SARS-CoV-2 omicron infection highlight presymptomatic and asymptomatic infectiousness

Li Jiang  1 , Lu Tang  2 , Linyu Zhu  3 , Yufang Zhu  4 , Song Yang  5 , Wenjie Chen  6 , Yi Fan  7 , Xuejiao Yang  8 , Shuai Yang  8 , Yulan Zheng  8 , Yunsheng Xu  9 , Peng Hong  10
Affiliations

Viral dynamics during SARS-CoV-2 omicron infection highlight presymptomatic and asymptomatic infectiousness

Li Jiang et al. J Infect. 2023 May.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare no competing interests.

Figures

Fig 1
Fig. 1
Peak viral RNA loads and timing according to symptomatic status or stage of outbreak. (A,B) Comparison of peak viral RNA levels (A) and time from viral RNA-positive to peak viral RNA (B) between asymptomatic (n = 668) and symptomatic cases (n = 294). Lines indicate geometric means ± 95% confidence intervals (A) or medians (B). Viral RNA concentration was calculated based on the Ct value of Orf1ab gene as described in the Supplementary Materials. Lower limit of viral RNA concentration was set at 19 copies/mL, which corresponded to cut-off Ct value of 38 for Orf1ab gene. (C) Comparison of peak viral RNA levels between asymptomatic (n = 668), pre-symptomatic peaking (n = 61) and post-symptomatic peaking cases (n = 233). The pre-symptomatic and post-symptomatic peaking cases together made the symptomatic group in (A). Lines indicate geometric means ± 95% confidence intervals. (D) Comparison of peak viral RNA levels between early- (≤5 days after lockdown, n = 436) and late-stage cases (n = 526). Lines indicate geometric means ± 95% confidence intervals. Statistical significance was assessed by Mann-Whitney U tests.
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References

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