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Review
. 2021 Dec 15;2(3):131-138.
doi: 10.2478/rir-2021-0019. eCollection 2021 Sep.

Systemic Lupus Erythematosus and Immunodeficiency

Shirley Chiu Wai Chan  1 , Chak Sing Lau  1
Affiliations
Review

Systemic Lupus Erythematosus and Immunodeficiency

Shirley Chiu Wai Chan et al. Rheumatol Immunol Res. .

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease caused by a combination of genetic, epigenetic, and environmental factors. Recent advances in genetic analysis coupled with better understanding of different immune regulatory and signaling pathways have revealed the complex relationship between autoimmunity, including SLE, and immunodeficiency. Furthermore, the expanding therapeutic armamentarium has led to the increasing awareness of secondary immunodeficiency in these patients. This article serves to update the current understanding of SLE and immunodeficiency by discussing the shared genetic factors and immunobiology. We also summarize the effects of immunosuppressive therapies with a focus on secondary antibody deficiency (SAD) after B-cell targeted therapies.

Keywords: immunodeficiency; infections; systemic lupus erythematosus.

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Conflict of interest statement

Conflict of Interest Chak Sing Lau is an Editorial Board Member of the journal. The article was subject to the journal’s standard procedures, with peer review handled independently of these members and their research groups.

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