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. 2022 Nov 28:18:2771-2781.
doi: 10.2147/NDT.S384705. eCollection 2022.

Effect of Personality Traits on Sustained Remission Among Patients with Major Depression: A 12-Month Prospective Study

Waka Nogami  1 , Atsuo Nakagawa  1   2 , Nariko Katayama  1 , Yuka Kudo  1   3   4 , Mizuki Amano  1   5 , Sakae Ihara  1 , Chika Kurata  1 , Yuki Kobayashi  1 , Yohei Sasaki  1 , Natsumi Ishikawa  1   6 , Yasunori Sato  7 , Masaru Mimura  1
Affiliations

Effect of Personality Traits on Sustained Remission Among Patients with Major Depression: A 12-Month Prospective Study

Waka Nogami et al. Neuropsychiatr Dis Treat. .

Abstract

Purpose: Major depression is a heterogeneous disorder. Therefore, careful evaluation and comprehensive assessment are crucial elements for achieving remission. Personality traits influence prognosis and treatment outcomes, but there is not enough evidence on the association between personality traits and sustained remission (SR). Hence, the present study aimed to evaluate the relationship between personality traits and SR among patients with major depression.

Patients and methods: The 12-month prospective study evaluated 77 patients diagnosed with major depressive disorder. All patients underwent a comprehensive assessment, including the Temperament and Personality Questionnaire (T&P) at baseline, and depression severity was measured at baseline as well as six and 12 months. SR was defined as remission (the GRID-Hamilton Depression Rating Scale [GRID-HAMD17] score ≦ 7) at both the 6- and 12-month follow-up. We compared eight T&P construct scores at baseline between the SR and non-SR groups. Multivariable logistic regression analyses were performed to determine the T&P personality traits related to SR.

Results: Patients who achieved SR had a lower T&P personal reserve and lower T&P rejection sensitivity. Further, lower scores on the T&P personal reserve trait were independently associated with higher rates of SR among patients with major depression. Patients who achieved SR had a shorter duration of the current depressive episode and milder severity of depression at baseline.

Conclusion: A lower level of personal reserve predicted a higher probability of SR in the treatment of depression. Extended observations in naturalistic follow-up settings with larger sample sizes are required to better understand the personality traits affecting SR in patients with depression.

Keywords: depression; personal reserve; personality traits; sustained remission; temperament and personality questionnaire.

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Conflict of interest statement

Prof. Dr. Masaru Mimura reports personal fees from Biogen Japan, personal fees from Byer Pharmaceutical, grants, personal fees from Daiichi Sankyo, personal fees from Dainippon-Sumitomo Pharma, personal fees from Demant Japan, grants, personal fees from Eisai, personal fees from Eli Lilly, personal fees from Fuji Film RI Pharma, personal fees from Hisamitsu Pharmaceutical, personal fees from H.U. Frontier, personal fees from Janssen Pharmaceutical, personal fees from Mochida Pharmaceutical, personal fees from MSD, personal fees from Mylan EPD, personal fees from Nippon Chemipher, personal fees from Novartis Pharma, personal fees from Ono Yakuhin, personal fees from Otsuka Pharmaceutical, personal fees from Pfizer, grants from Shionogi, grants from Takeda Yakuhin, personal fees from Teijin Pharma, personal fees from Viatris, personal fees from Fronteo, grants from Tanabe Mitsubishi, grants from Tsumura, outside the submitted work. All authors declare that they have no conflicts of interest regarding this study.

Figures

Figure 1
Figure 1
Changes in depressive symptoms based on the mean GRID-HAMD17 scores.
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