Brain fog as a Long-term Sequela of COVID-19
- PMID: 36466122
- PMCID: PMC9685075
- DOI: 10.1007/s42399-022-01352-5
Brain fog as a Long-term Sequela of COVID-19
Abstract
Increasing data indicate that people infected with COVID-19 are at high risk for developing long-term neurological complications, such as "brain fog" or cognitive impairment. However, little is known about the long-term outcomes of COVID-19 survivors. This also applies to the prevalence, risk factors, and pathobiological findings associated with these consequences. Although cognitive complications are anticipated in patients who require a long-lasting hospital stay or intubation, milder cases of COVID-19 with no record of hospitalization have also been shown to experience assessable cognitive challenges. Cognitive impairment can have a devastating impact on daily functioning. Understanding the long-term effect of COVID-19 on cognitive function is vital for applying specific schemes to those who wish to return to their jobs productively.
Keywords: Brain fog; COVID-19; Cognitive impairment; Long COVID; Pathophysiology; SARS-CoV-2; Systemic inflammation; Virus infection.
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Conflict of interest statement
Conflict of InterestThe author declares no competing interests.
Similar articles
-
A proposal to apply brain injury recovery treatments for cognitive impairment in COVID-19 survivors.Int J Neurosci. 2024 Jun;134(1):88-89. doi: 10.1080/00207454.2022.2084091. Epub 2022 Jun 5. Int J Neurosci. 2024. PMID: 35635529
-
Brain Fog: a Narrative Review of the Most Common Mysterious Cognitive Disorder in COVID-19.Mol Neurobiol. 2024 Dec;61(12):9915-9926. doi: 10.1007/s12035-023-03715-y. Epub 2023 Oct 24. Mol Neurobiol. 2024. PMID: 37874482 Review.
-
Long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection.Front Immunol. 2023 Apr 28;14:1147549. doi: 10.3389/fimmu.2023.1147549. eCollection 2023. Front Immunol. 2023. PMID: 37187756 Free PMC article.
-
Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce 'Brain Fog' and Results in Behavioral Changes that Favor Viral Survival.Med Sci Monit. 2021 Jan 25;27:e930886. doi: 10.12659/MSM.930886. Med Sci Monit. 2021. PMID: 33487628 Free PMC article.
-
Vascular Dysfunctions Contribute to the Long-Term Cognitive Deficits Following COVID-19.Biology (Basel). 2023 Aug 9;12(8):1106. doi: 10.3390/biology12081106. Biology (Basel). 2023. PMID: 37626992 Free PMC article. Review.
Cited by
-
Long-term COVID-19 sequelae by Theta and SARS-CoV-2 variants in a Philippine cohort.Front Med (Lausanne). 2024 Oct 2;11:1455729. doi: 10.3389/fmed.2024.1455729. eCollection 2024. Front Med (Lausanne). 2024. PMID: 39421860 Free PMC article.
-
Advanced magnetic resonance neuroimaging techniques: feasibility and applications in long or post-COVID-19 syndrome - a review.Ann Med Surg (Lond). 2024 Feb 9;86(3):1584-1589. doi: 10.1097/MS9.0000000000001808. eCollection 2024 Mar. Ann Med Surg (Lond). 2024. PMID: 38463042 Free PMC article. Review.
-
Deep into Cognition: The Neuropsychological Identikit of Younger and Older Individuals after COVID-19 Infection.Biology (Basel). 2024 Sep 24;13(10):754. doi: 10.3390/biology13100754. Biology (Basel). 2024. PMID: 39452064 Free PMC article.
-
Long COVID management: a mini review of current recommendations and underutilized modalities.Front Med (Lausanne). 2024 Jun 14;11:1430444. doi: 10.3389/fmed.2024.1430444. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38947233 Free PMC article. Review.
-
Long COVID: An approach to clinical assessment and management in primary care.S Afr Fam Pract (2004). 2023 Jun 23;65(1):e1-e10. doi: 10.4102/safp.v65i1.5751. S Afr Fam Pract (2004). 2023. PMID: 37427773 Free PMC article.
References
-
- Perego E, Callard F, Stras L, et al. Why the patient-made term ‘long covid’ is needed. Wellcome Open Res. 2020;5:224. doi: 10.12688/wellcomeopenres.16307.1. - DOI
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous