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Review
. 2023 Jan;13(1):1.
doi: 10.1007/s13205-022-03398-7. Epub 2022 Dec 1.

Antibacterial potential of chalcones and its derivatives against Staphylococcus aureus

Larissa da Silva  1 , Isydorio Alves Donato  1 , Cicera Alane Coelho Gonçalves  1 , Jackelyne Roberta Scherf  2 , Hélcio Silva Dos Santos  3 , Edna Mori  4 , Henrique Douglas Melo Coutinho  5 , Francisco Assis Bezerra da Cunha  1
Affiliations
Review

Antibacterial potential of chalcones and its derivatives against Staphylococcus aureus

Larissa da Silva et al. 3 Biotech. 2023 Jan.

Abstract

Chalcones are natural substances found in the metabolism of several botanical families. Their structure consists of 1,3-diphenyl-2-propen-1-one and they are characterized by having in their chains an α, β-unsaturated carbonyl system, two phenol rings and a three-carbon chain that unites them. In plants, Chalcones are mainly involved in the biosynthesis of flavonoids and isoflavonoids through the phenylalanine derivation. This group of substances has been shown to be a viable alternative for the investigation of its antibacterial potential, considering the numerous biological activities reported and the increase of the microbial resistance that concern global health agencies. Staphylococcus aureus is a bacterium that has stood out for its ability to adapt and develop resistance to a wide variety of drugs. This literature review aimed to highlight recent advances in the use of Chalcones and derivatives as antibacterial agents against S. aureus, focusing on research articles available on the Science Direct, Pub Med and Scopus data platforms in the period 2015-2021. It was constructed informative tables that provided an overview of which types of Chalcones are being studied more (Natural or Synthetic); its chemical name and main Synthesis Methodology. From the analysis of the data, it was observed that the compounds based on Chalcones have great potential in medicinal chemistry as antibacterial agents and that the molecular skeletons of these compounds as well as their derivatives can be easily obtained through substitutions in the A and B rings of Chalcones, in order to obtain the desired bioactivity. It was verified that Chalcones and derivatives are promising agents for combating the multidrug resistance of S. aureus to drugs.

Supplementary information: The online version contains supplementary material available at 10.1007/s13205-022-03398-7.

Keywords: Bioactivity; Efflux pump; Multi-resistance; Structure–activity relationship.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no known conflict of interest to disclose.

Figures

Fig. 1
Fig. 1
Fundamental structure of chalcones. Source: Author (2022)
Fig. 2
Fig. 2
- PRISMA flowchart of the analytical steps for building the review. Source: Author (2022)
See this image and copyright information in PMC

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