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Review
. 2022 Nov 17:10:1023332.
doi: 10.3389/fcell.2022.1023332. eCollection 2022.

Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer

Takahiro Seimiya  1 , Motoyuki Otsuka  1 , Mitsuhiro Fujishiro  1
Affiliations
Review

Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer

Takahiro Seimiya et al. Front Cell Dev Biol. .

Abstract

Circular RNAs are single-stranded RNAs with a covalently closed structure formed by the process of back-splicing. Aberrant expression of circular RNAs contributes to the pathogenesis of a wide range of cancers. Pancreatic cancer is one of the most lethal cancers due to diagnostic difficulties and limited therapeutic options. Circular RNAs are emerging as novel diagnostic biomarkers and therapeutic targets for pancreatic cancer. Moreover, recent advances in the therapeutic application of engineered circular RNAs have provided a promising approach to overcoming pancreatic cancer. This review discusses the roles of circular RNAs in the pathogenesis of pancreatic cancer and in potential treatment applications and their usefulness as diagnostic biomarkers.

Keywords: biomarker; circRNA; circular RNA; pancreatic cancer; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Roles of pathogenic circRNAs in pancreatic cancerPathogenic circRNAs in pancreatic cancer function as miRNA decoys and interact with proteins to stabilize mRNA, inhibit post-translational modifications (PTMs), and provide scaffolds for protein complex formation.
FIGURE 2
FIGURE 2
Effects of circRNAs on the tumor microenvironment in pancreatic cancercircFARP enhances LIF expression in cancer-associated fibroblasts. circNFIB1 enhances VEGF-C expression in pancreatic cancer cells. circZNF91 and circPDE8A are transmitted from pancreatic cancer cells to nearby cancer cells. circIARS is transmitted from pancreatic cancer cells to endothelial cells.
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