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Review
. 2021 Apr 13;2(1):19-25.
doi: 10.2478/rir-2021-0003. eCollection 2021 Mar.

Rethink About the Role of Rheumatoid Factor and Anti-citrullinated Protein Antibody in Rheumatoid Arthritis

Wang Yu Sung  1 , Wen Chan Tsai  1
Affiliations
Review

Rethink About the Role of Rheumatoid Factor and Anti-citrullinated Protein Antibody in Rheumatoid Arthritis

Wang Yu Sung et al. Rheumatol Immunol Res. .

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint inflammation and extra-articular manifestations. Many questions in the pathogenesis, clinical manifestation, and disease spectrum are answered after the discovery of the first autoantibody namely rheumatoid factor (RF). The finding of the second autoantibody named anti-citrullinated protein antibody (ACPA), which unearths the importance of protein citrullination process. It further provides the insight how immune cells and complement interact to perpetuate the inflammatory response. These two autoantibodies pave the way for our better understanding of RA. This review article focuses on the history, pathophysiology, and clinical association of these two autoantibodies in RA.

Keywords: anti-citrullinated protein antibody; rheumatoid arthritis; rheumatoid factor.

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Conflict of interest statement

Conflict of Interest No potential conflicts of interest were disclosed.

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References

    1. Lee DM, Weinblatt ME. Rheumatoid Arthritis. Lancet. 2001;358(9285):903–911. - PubMed
    1. Wasserman AM. Diagnosis and Management of RA. Am Fam Physician. 2011;84(11):1245–1252. - PubMed
    1. Scott DL, Wolfe F, Huizinga TW. Rheumatoid Arthritis. Lancet. 2010;376(9746):1094–1108. - PubMed
    1. Ibrahim M, Suzuki A, Yamada K. et al. The Relationship Between Cervical and Lumbar Spine Lesions in Rheumatoid Arthritis with A Focus on Endplate Erosion. J Spinal Disord Tech. 2015;28(3):E154–E160. - PubMed
    1. Seki S, Hirano N, Matsushita I. et al. Lumbar Spine Surgery in Patients with Rheumatoid Arthritis (RA): What Affects the Outcomes? Spine J. 2018;18(1):99–106. - PubMed

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