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. 1978 Oct;58(5):879-93.
doi: 10.1016/s0039-6109(16)41629-4.

Personal reflections in transplantation

T E Starzl

Personal reflections in transplantation

T E Starzl. Surg Clin North Am. 1978 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Rejection crisis in patient (LD 1) treated initially with total body irradiation (400 R). Note transient oliguria, depression of creatinine clearance, and elevation of blood urea nitrogen, blood pressure, and urinary protein excretion. The changes were all reversible. The patient previously had undergone bilateral nephrectomy, splenectomy, and thymectomy. R, dose total body irradiation; Acti-C, actinomycin C (each arrow equals 200 μg of actinomycin C administered intravenously). Imuran is synonymous with azathioprine. These general events of rejection have occurred despite treatment with all the therapeutic regimens used at this and other centers since 1962. (From Starzl, T. E., et al.: The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg. Gynecol. Obstet., 117:385, 1963, with permission.)
Figure 2
Figure 2
Classic rejection crisis in patient (LD 6) treated with drugs alone. Deterioration of renal function began 19 days after transplantation. All stigmata of rejection are present except for acute hypertension and weight gain, which were successfully prevented by medical treatment. Acti-C, actinomycin C; LN, left nephrectomy at time of transplantation; RN, Right nephrectomy. Imuran is synonymous with azathioprine. (From Starzl, T. E., et al.: The reversal of rejection in human renal homografts with subsequent development of homograft tolerance. Surg. Gynecol. Obstet., 117:385, 1963, with permission.)
Figure 3
Figure 3
Orthotopic liver transplantation with biliary duet reconstruction by choledochocholedochostomy after cholecystectomy. Other acceptable techniques of biliary reconstruction involve anastomosis of the homograft gallbladder or common duct to a Roux-Y jejunal limb.
See this image and copyright information in PMC

References

    1. Absolon KB, Hagihara PF, Griffen WO, Jr., et al. Experimental and clinical heterotopic liver homotransplantation. Rev. Int. Hepat. 1965;15:1481. - PubMed
    1. Belzer FO, Ashby BS, Dunphy JE. 24-hour and 72-hour preservation of canine kidneys. Lancet. 1967;2:536. - PubMed
    1. Billingham RE, Krohn PL, Medawar PB. Effect of cortisone on survival of skin homografts in rabbits. Br. Med. J. 1951;1:1157. - PMC - PubMed
    1. Calne RY. The rejection of renal homografts; inhibition in dogs by 6-mercaptopurine. Lancet. 1960;1:417. - PubMed
    1. Calne RY, Murray JE. Inhibition of the rejection of renal homografts in dogs by Burroughs Wellcome 57-322. Surg. Forum. 1961;12:118. - PubMed

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