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. 2022 Dec;52(12):101313.
doi: 10.1016/j.cppeds.2022.101313. Epub 2022 Dec 5.

Pulmonological issues

Geovanny Perez  1 , Lisa Young  2 , Richard Kravitz  3 , Daniel Sheehan  4 , Laura Adang  2 , Keith Van Haren  5 , Jody L Lin  6 , Nicole Nikki Jaffe  2 , Dennis Kuo  4 , Laura Ball  7 , Jennifer Keller  8 , Jeffrey Sank  3 , Donna DiVito  2 , Samira Naime  9
Affiliations

Pulmonological issues

Geovanny Perez et al. Curr Probl Pediatr Adolesc Health Care. 2022 Dec.

Abstract

Pediatric leukodystrophies are rare neurodegenerative diseases involving multiple systems. Each form has unique neurologic features but are characterized by encephalopathy with accompanying impairments evidenced in reflexes, muscle tone and movement control. Weakness of expiratory, inspiratory, and upper airway muscles may lead to impaired airway secretion clearance resulting in recurrent respiratory infections, dysphagia, sleep-disordered breathing, restrictive lung disease, and ultimately chronic respiratory insufficiency.

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References

    1. Vanderver A, Tonduti D, Schiffmann R, Schmidt J, van der Knaap MS, et al. Leukodystrophy overview – retired chapter, for historical reference only. In: Adam MP, Ardinger HH, Pagon RA, (eds). GeneReviews(®), Seattle (WA): University of Washington, Seattle, 1993.Copyright © 1993–2022, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.
    1. Winfield NR, Barker NJ, Turner ER, Quin GL. Non-pharmaceutical management of respiratory morbidity in children with severe global developmental delay. Cochrane Database Syst Rev 2014;2014(10):Cd010382. - PMC - PubMed
    1. Dias BLS, Fernandes AR, Maia HSF. Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy. Arq Neuropsiquiatr 2017;75(5):282–7. - PubMed
    1. McGeachan AJ, McDermott CJ. Management of oral secretions in neurological disease. Pract Neurol 2017;17(2):96–103. - PubMed
    1. Walshe M, Smith M, Pennington L. Interventions for drooling in children with cerebral palsy. Cochrane Database Syst Rev 2012;11:Cd008624. - PMC - PubMed