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Comment
. 2022 Dec 2;61(6):e85-e86.
doi: 10.1515/cclm-2022-1025. Print 2023 May 25.

A new method for early cancer detection based on platelet transcriptomics will have low positive predictive value

Eleftherios P Diamandis  1
Affiliations
Comment

A new method for early cancer detection based on platelet transcriptomics will have low positive predictive value

Eleftherios P Diamandis. Clin Chem Lab Med. .
No abstract available

Keywords: cancer screening; educated platelets; predictive value.

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Comment on

  • Detection and localization of early- and late-stage cancers using platelet RNA.
    In 't Veld SGJG, Arkani M, Post E, Antunes-Ferreira M, D'Ambrosi S, Vessies DCL, Vermunt L, Vancura A, Muller M, Niemeijer AN, Tannous J, Meijer LL, Le Large TYS, Mantini G, Wondergem NE, Heinhuis KM, van Wilpe S, Smits AJ, Drees EEE, Roos E, Leurs CE, Tjon Kon Fat LA, van der Lelij EJ, Dwarshuis G, Kamphuis MJ, Visser LE, Harting R, Gregory A, Schweiger MW, Wedekind LE, Ramaker J, Zwaan K, Verschueren H, Bahce I, de Langen AJ, Smit EF, van den Heuvel MM, Hartemink KJ, Kuijpers MJE, Oude Egbrink MGA, Griffioen AW, Rossel R, Hiltermann TJN, Lee-Lewandrowski E, Lewandrowski KB, De Witt Hamer PC, Kouwenhoven M, Reijneveld JC, Leenders WPJ, Hoeben A, Verdonck-de Leeuw IM, Leemans CR, Baatenburg de Jong RJ, Terhaard CHJ, Takes RP, Langendijk JA, de Jager SC, Kraaijeveld AO, Pasterkamp G, Smits M, Schalken JA, Łapińska-Szumczyk S, Łojkowska A, Żaczek AJ, Lokhorst H, van de Donk NWCJ, Nijhof I, Prins HJ, Zijlstra JM, Idema S, Baayen JC, Teunissen CE, Killestein J, Besselink MG, Brammen L, Bachleitner-Hofmann T, Mateen F, Plukker JTM, Heger M, de Mast Q, Lisman T, Pegtel DM, Bogaard HJ, Jassem J, Supernat A, Mehra N, Gerritsen W, de Kroon CD, Lok CAR, Piek JMJ, Steeghs N, van Houdt WJ, Br… See abstract for full author list ➔ In 't Veld SGJG, et al. Cancer Cell. 2022 Sep 12;40(9):999-1009.e6. doi: 10.1016/j.ccell.2022.08.006. Epub 2022 Sep 1. Cancer Cell. 2022. PMID: 36055228

References

    1. In ’t Veld, SGJG, Arkani, M, Post, E, Antunes-Ferreira, M, D’Ambrosi, S, Vessies, DCL, et al.. Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell 2022;40:999–1009.e6. https://doi.org/10.1016/j.ccell.2022.08.006 . - DOI
    1. Fernandez-Uriarte, A, Pons-Belda, OD, Diamandis, EP. Cancer screening companies are rapidly proliferating: are they ready for business? Cancer Epidemiol Biomarkers Prev 2022;31:1146–50. https://doi.org/10.1158/1055-9965.epi-22-0102 . - DOI
    1. Anonymous. NCI to study cancer blood tests. Science 2022;377:8.
    1. Wilson, JMG, Jungner, G, World Health Organization. Principles and practice of screening for disease; 1968. Available from: https://apps.who.int/iris/handle/10665/37650 .
    1. Fiala, C, Diamandis, EP. A multi-cancer detection test: focus on the positive predictive value. Ann Oncol 2020;31:1267–8. https://doi.org/10.1016/j.annonc.2020.05.028 . - DOI

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