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Review
. 2023 May 1;38(3):0.
doi: 10.1152/physiol.00020.2022. Epub 2022 Dec 6.

RANKL and RANK in Cancer Therapy

Masahiro Onji  1 , Josef M Penninger  1   2
Affiliations
Free article
Review

RANKL and RANK in Cancer Therapy

Masahiro Onji et al. Physiology (Bethesda). .
Free article

Abstract

Receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) are key regulators of mammalian physiology such as bone metabolism, immune tolerance and antitumor immunity, and mammary gland biology. Here, we explore the multiple functions of RANKL/RANK in physiology and pathophysiology and discuss underlying principles and strategies to modulate the RANKL/RANK pathway as a therapeutic target in immune-mediated cancer treatment.

Keywords: BRCA1; denosumab; immune tolerance; intestinal homeostasis; osteology.

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