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. 2022 Dec 6;22(1):502.
doi: 10.1186/s12876-022-02589-z.

Magnetic controlled capsule endoscope (MCCE)'s diagnostic performance for H. pylori infection status based on the Kyoto classification of gastritis

Sun Xi #  1 , Liu Jing #  1 , Wu Lili  1 , Li Tingting  1 , Li Jun  1 , Wang Ming  1 , Wang Zhiqiang  2 , Jin Peng  3
Affiliations

Magnetic controlled capsule endoscope (MCCE)'s diagnostic performance for H. pylori infection status based on the Kyoto classification of gastritis

Sun Xi et al. BMC Gastroenterol. .

Abstract

Background: Previous studies have shown that the Kyoto classification of gastritis can accurately predict H. pylori infection status on conventional gastroscopy. The aim of this study was to test whether the Kyoto classification of gastritis applies well to magnetic controlled capsule endoscopy (MCCE).

Methods: We consecutively recruited 227 participants who underwent both MCCE and urea breath tests (UBTs). Two physicians who were blinded to the UBT results independently made the diagnosis of H. pylori infection status according to 10 findings listed in the Kyoto classification of gastritis after reviewing MCCE images. We also developed 2 predictive models to assess H. pylori infection status by combining these 10 findings.

Results: The MCCE's overall diagnostic accuracy for H. pylori infection status was 80.2%. The sensitivity, specificity and diagnostic odds ratio (DOR) for current infection were 89.4%, 90.1% and 77.1, respectively. Major specific findings were mucosal swelling and spotty redness for current infection, regular arrangement of collecting venules (RAC), streak redness, fundic gland polyp (FGP) for noninfection, and map-like redness for past-infection. In the two prediction models, the area under the curve (AUC) values for predicting noninfection and current infection were 84.7 and 84.9, respectively.

Conclusions: The Kyoto classification of gastritis applied well to MCCE. H. pylori infection status could be accurately assessed on MCCE according to the Kyoto classification of gastritis.

Keywords: Early detection; Gastric cancer; H. pylori; Kyoto classification of gastritis; Magnetic controlled capsule endoscope.

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Conflict of interest statement

All authors of this study declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
MCCE’s Kyoto classification of gastritis. (A–H, EGD images; a–h MCCE images). A, a mucosal swelling; B, b enlarged folds with spotty redness; C, c nodularity; D, d diffusive redness; E, e map-like redness; F, f xanthoma; G, g RAC; H, h FGP
Fig. 2
Fig. 2
Receiver operating characteristic (ROC) curves for predicting noninfection (A) and current infection (B) based on 10 findings in the Kyoto classification of gastritis. AUC, area under the curve
See this image and copyright information in PMC

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