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. 2022 Jan-Dec:21:23259582221143673.
doi: 10.1177/23259582221143673.

The Outcomes of Transition from Pediatrics to Adult Care among Adolescents and Young Adults with HIV at a Tertiary Care Center in Bangkok

Supattra Rungmaitree  1 , Nuchanat Thamniamdee  1 , Saranya Sachdev  2 , Wanatpreeya Phongsamart  1 , Keswadee Lapphra  1 , Orasri Wittawatmongkol  1 , Alan Maleesatharn  1 , Benjawan Khumcha  1 , Risa M Hoffman  3 , Kulkanya Chokephaibulkit  1   4
Affiliations

The Outcomes of Transition from Pediatrics to Adult Care among Adolescents and Young Adults with HIV at a Tertiary Care Center in Bangkok

Supattra Rungmaitree et al. J Int Assoc Provid AIDS Care. 2022 Jan-Dec.

Abstract

Background: Adolescents and young adults with HIV (AYHIV) are at high-risk of loss to follow up and virologic failure, particularly during transition from pediatric to adult clinics. Methods: We reviewed the medical records of AYHIV to characterize retention and virologic suppression following their transition. Results: 101 AYHIV, 97% perinatally infected, were transferred at the median age of 20 (IQR: 19-21) years. At 1-year post-transition, 92.1% were retained in care and 73.3% had viral suppression and at 2-years the retention and viral suppression were 87.1% and 76.7%, respectively. Factors associated with viral suppression were transition at ≥ 20 years of age (aOR 4.38, 95% CI 1.41-13.65) and receiving first-line ART regimen, compared to second- or third-line regimens, at transition (aOR 6.05, 95% CI 1.55-23.58). Conclusion: Transition outcomes of AYHIV in our setting were suboptimal. There is a need for interventions to support AYHIV transition during this vulnerable period.

Keywords: HIV; Thailand; Transition; adolescents; outcome.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

The study was approved by the Siriraj Institutional Review Board (approval no. 441/2561).

Figures

Figure 1.
Figure 1.
One- and two-year outcomes after transition (left) and the percentage of viral suppression at 1-, and 2-year post-transition (right).
Figure 2.
Figure 2.
The percentage of patients without any of the three composite outcomes (death, loss to follow up, or virological failure) compared with ART regimens.
See this image and copyright information in PMC

References

    1. Heath K, Levi J, Hill A. The Joint United Nations Programme on HIV/AIDS 95-95-95 targets: Worldwide clinical and cost benefits of generic manufacture. AIDS. 2021;35(Suppl 2):S197–S203. doi:10.1097/QAD.0000000000002983 - DOI - PubMed
    1. Boerma RS, Boender TS, Bussink AP, et al. Suboptimal viral suppression rates among HIV-infected children in low- and middle-income countries: A meta-analysis. Clin Infect Dis. 2016;63(12):1645–1654. doi:10.1093/cid/ciw645 - DOI - PubMed
    1. Enane LA, Vreeman RC, Foster C. Retention and adherence: Global challenges for the long-term care of adolescents and young adults living with HIV. Curr Opin HIV AIDS. 2018;13(3):212–219. doi:10.1097/COH.0000000000000459 - DOI - PubMed
    1. Committee on Pediatric Aids. Transitioning HIV-infected youth into adult health care. Pediatrics. 2013;132(1):192–197. doi:10.1542/peds.2013-1073 - DOI - PubMed
    1. Hansudewechakul R, Pongprapass S, Kongphonoi A, Denjanta S, Watanaporn S, Sohn AH. Transition of Thai HIV-infected adolescents to adult HIV care. J Int AIDS Soc. 2015;18(1):20651. doi:10.7448/IAS.18.1.20651 - DOI - PMC - PubMed