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. 2022 Nov 30:15:6963-6974.
doi: 10.2147/IDR.S387898. eCollection 2022.

Clinical Characteristics and Prognosis Analysis of Acinetobacter baumannii Bloodstream Infection Based on Propensity Matching

Jinghui Wang  1 , Jun Zhang  2 , Zhuang-Hao Wu  1 , Lei Liu  3 , Zijun Ma  1 , Cheng-Cheng Lai  1 , Yong-Gang Luo  1
Affiliations

Clinical Characteristics and Prognosis Analysis of Acinetobacter baumannii Bloodstream Infection Based on Propensity Matching

Jinghui Wang et al. Infect Drug Resist. .

Abstract

Purpose: In view of the fact that Acinetobacter baumannii bloodstream infection(BSI) is a great threat to human survival, early identification of the risk factors affecting prognosis will be of great benefit to the clinic.

Patients and methods: A propensity score matching method was used to collect patients identified with Acinetobacter baumannii BSI from 2016 to 2020 from a reputable hospital in China.

Results: A total of 398 patients were considered. According to the 28-day prognosis, they were divided into the survival group 150 (37.7%) and the death group 248 (62.3%), and the prognosis was analyzed. Subsequently, Propensity score matching was adjusted for variables with p-values <O.2 in the baseline data, equalized differences in baseline, multivariate paired logistics regression analysis was performed on 63 matched patients and showed that patients with Acinetobacter baumannii BSI who had higher SOFA scores at the time of infection, with septic shock, or mechanical ventilation were more likely to be fatally hit within 28 days and had a poor prognosis.

Conclusion: The existence of drug resistance with Acinetobacter baumannii only leads to Inappropriate empirical antibiotic therapy, ultimately, Inappropriate empirical antibiotic therapy was the direct predictor of mortality.

Keywords: Acinetobacter baumannii; bloodstream infection; inappropriate empirical antibiotic therapy; prognosis; propensity score matching.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Study design of Acinetobacter baumannii BSI patients.
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