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. 2022 Dec 16;24(49):9007-9011.
doi: 10.1021/acs.orglett.2c03631. Epub 2022 Dec 7.

Sinudenoids A-E, C19-Norcembranoid Diterpenes with Unusual Scaffolds from the Soft Coral Sinularia densa

Ci-Li Wang  1   2 , Tian-Yun Jin  1   2 , Xue-Huan Liu  1   2 , Jia-Rui Zhang  1   2 , Xing Shi  1   2 , Meng-Fei Wang  3 , RunFeng Huang  4 , Yun Zhang  3 , Ke-Chun Liu  3 , Guo-Qiang Li  1   2
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Sinudenoids A-E, C19-Norcembranoid Diterpenes with Unusual Scaffolds from the Soft Coral Sinularia densa

Ci-Li Wang et al. Org Lett. .

Abstract

Five new furanobutenolide-derived C19-norcembranoid diterpenes, sinudenoids A-E (1-5, respectively), were isolated from the soft coral Sinularia densa. Sinudenoid A (1) possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B-D (2-4, respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E (5) is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds 1-6 is proposed. Compound 5 exhibits strong anti-inflammatory activity in the zebrafish model.

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