Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 7;22(1):913.
doi: 10.1186/s12879-022-07690-y.

Trends in hepatitis B notification rates in Guangzhou, China, between 2009 and 2020: an epidemiological study

Wei Liu  1 , Zhiqiang Dong  1 , Wensui Hu  1 , Ke Li  1 , Lili Sun  1 , Jianrong Hou  1 , Shijie Jia  2 , Yuan Liu  3
Affiliations

Trends in hepatitis B notification rates in Guangzhou, China, between 2009 and 2020: an epidemiological study

Wei Liu et al. BMC Infect Dis. .

Abstract

Background: Although the prevalence of hepatitis B in Guangzhou, China, is high, the epidemiological trends are not well-documented. We aimed to analyse newly reported hepatitis B cases in Guangzhou between 2009 and 2020 to explore the epidemiological trends and provide insights for the development of control measures.

Methods: Information on the population and new cases of hepatitis B in Guangzhou between 2009 and 2020 was obtained from the China Information System for Disease Control and Prevention, which was used to calculate the annual notification rates of hepatitis B by sex, age group (0-9; 10-19; 20-29; 30-39; 40-49; 50-59; ≥ 60 years), and location (urban or rural). Joinpoint regression analysis was used to analyse the temporal trends and calculate the average annual percentage change (AAPC) and annual percentage change (APC) for each identified trend line segment.

Results: Between 2009 and 2020, 287,034 new cases of hepatitis B were cumulatively reported. The average annual notification rate was 181.13/100,000, and the notification rate showed a long-term downward trend during the period 2009-2020, with an annual decrease of 6.30% (APC - 6.30%; 95% CI - 7.56 to - 5.02%). Men had a significantly higher notification rate than women; however, the sex ratio decreased from a maximum of 2.34 in 2010 to a minimum of 1.54 in 2020. A downward trend in the notification rate was observed in urban areas and an upward trend was observed in rural areas, with an increase in the rural/urban ratio from 0.46 in 2012 to 1.57 in 2020. The notification rate for all age groups showed a decreasing trend from 2009, with the exception of the 50-59 years and ≥ 60 years groups, whose notification rates began to decrease from 2014 and 2015, respectively.

Conclusions: Although the overall notification rate of hepatitis B in Guangzhou decreased annually, it remained high. Further, in rural areas, the notification rate has been increasing, and effective measures should be taken to control hepatitis B infection in Guangzhou.

Keywords: Epidemiology; Hepatitis B; Joinpoint regression; Temporal trends.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Geographical location of the study area (Guangzhou, Guangdong)
Fig. 2
Fig. 2
Joinpoint model estimates in Guangzhou during 2006–2020. a Trends in the overall notification rate. b Trends in the notification rate stratified by sex. c Trends in the notification rate stratified by location. d Trends in the notification rate stratified by age
Fig. 3
Fig. 3
Trends in the notification rate. a Trends in the sex ratio. b Trends in the location ratio
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Zhang Q, Qi W, Wang X, Zhang Y, Xu Y, Qin S, Zhao P, Guo H, Jiao J, Zhou C, et al. Epidemiology of hepatitis B and hepatitis C infections and benefits of programs for hepatitis prevention in Northeastern China: a cross-sectional study. Clin Infect Dis. 2016;62(3):305–312. doi: 10.1093/cid/civ859. - DOI - PubMed
    1. Delaney WE, Borroto-Esoda K. Therapy of chronic hepatitis B: trends and developments. Curr Opin Pharmacol. 2008;8(5):532–540. doi: 10.1016/j.coph.2008.09.008. - DOI - PubMed
    1. WHO: Hepatitis B. vol. 2022; 2021.
    1. Peng T, Cai Q, Yang M, Chen S, Chen F, Wang M, Peng L, Wong G, Shen C, Cheng W, et al. Epidemiological trends and virological traits of hepatitis B virus infection in pregnant women and neonates. Arch Virol. 2019;164(5):1335–1341. doi: 10.1007/s00705-019-04190-4. - DOI - PubMed
    1. Arciuolo RJ, Lazaroff JE, Rosen JB, Lim S, Zucker JR. Trends in hepatitis B surveillance among pregnant women in New York City, 1998–2015. Public Health Rep. 2020;135(5):676–684. doi: 10.1177/0033354920946793. - DOI - PMC - PubMed