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Editorial
. 2023 Mar 15;207(6):655-657.
doi: 10.1164/rccm.202211-2126ED.

Cardiopulmonary Pathogenic Networks: Unveiling the Gut-Lung Microbiome Axis in Pulmonary Arterial Hypertension

Suellen Darc Oliveira  1
Affiliations
Editorial

Cardiopulmonary Pathogenic Networks: Unveiling the Gut-Lung Microbiome Axis in Pulmonary Arterial Hypertension

Suellen Darc Oliveira. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Cardiopulmonary pathogenic networks as crossroads for the gut–lung microbial interaction. Schematic showing the human cardiovascular (red = arteries; blue = veins) and lymphatic systems (gray) as potential pathways for pathogen and metabolite translocation from a disrupted gut microbiome (i.e., gut microbiome dysbiosis) into the lung tissue. Ongoing studies indicate that gut-derived pathogens and pathogen-associated molecular patterns contribute to elevated circulating proinflammatory cytokines and reduced antiinflammatory molecules such as short-chain fatty acids, which may trigger or even potentiate the pulmonary inflammatory vasculopathy that characterizes pulmonary arterial hypertension. Top inset: inflamed and remodeled pulmonary vasculature. Bottom inset: gut-derived microbiota.
See this image and copyright information in PMC

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