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. 2023 Jan 5;388(1):89-91.
doi: 10.1056/NEJMc2214302. Epub 2022 Dec 7.

Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB

Masaki Imai  1 , Mutsumi Ito  1 , Maki Kiso  1 , Seiya Yamayoshi  1 , Ryuta Uraki  1 , Shuetsu Fukushi  2 , Shinji Watanabe  2 , Tadaki Suzuki  2 , Ken Maeda  2 , Yuko Sakai-Tagawa  1 , Kiyoko Iwatsuki-Horimoto  1 , Peter J Halfmann  3 , Yoshihiro Kawaoka  4
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Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB

Masaki Imai et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. In Vitro Efficacy of Therapeutic Monoclonal Antibodies and Antiviral Drugs against Omicron Subvariants.
Panel A shows the neutralizing activity of monoclonal antibodies against omicron subvariants. The antibodies used in this analysis were produced in the authors’ laboratories and are not identical to the commercially available products. The 50% focus reduction neutralization test (FRNT50) titer levels were determined by performing a focus reduction neutralization test in Vero E6 cells engineered to express transmembrane serine protease 2 (TMPRSS2) and human angiotensin-converting enzyme 2 (ACE2). The data shown are the mean values for triplicate experiments. Panel B shows the inhibitory activity of antiviral drugs against omicron subvariants. The drugs used were purchased from MedChemExpress. The in vitro 50% inhibitory concentration (IC50) values were determined by performing a focus reduction assay in Vero E6 cells engineered to express TMPRSS2 and ACE2. The data shown are the mean values for triplicate experiments. GS-441524 (the main metabolite of remdesivir) and EIDD-1931 (the active form of molnupiravir) are RNA-dependent RNA polymerase inhibitors. PF-07321332 (nirmatrelvir) is a main protease inhibitor.
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References

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