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Comment
. 2022 Dec 6;34(12):1899-1900.
doi: 10.1016/j.cmet.2022.11.007.

Not so neutral lipids: Metabolic regulation of the pre-metastatic niche

Joshua D Schoenfeld  1 , Santosha A Vardhana  2
Affiliations
Comment

Not so neutral lipids: Metabolic regulation of the pre-metastatic niche

Joshua D Schoenfeld et al. Cell Metab. .

Abstract

How primary tumors alter distant tissue sites to facilitate seeding and metastasis remains unclear. In this issue, Gong et al. demonstrate that IL-1β-dependent lipid accumulation in lung mesenchymal cells supports both tumor growth and NK cell dysfunction, facilitating lung metastasis of primary breast tumors.

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Conflict of interest statement

Declaration of interests S.A.V. is an advisor for Immunai and has received consulting fees from ADC Therapeutics and Koch Disruptive Technologies.

Figures

Figure 1.
Figure 1.. Primary breast tumors metabolically regulate the pre-metastatic niche by promoting stromal lipid accumulation
In this issue, Gong et al. demonstrate that systemic IL-1β, both tumor and myeloid derived, induces neutral lipid accumulation in lung mesenchymal cells in the pre-metastatic niche through inhibition of ATGL. Accumulated lipids are transported to both tumor and NK cells within the pre-metastatic niche, supporting bioenergetic support to nascent metastases while suppressing NK cell function. The group had previously demonstrated that, under the same conditions, neutrophils in the pre-metastatic niche can also supply lipids to support metastatic tumor growth.
See this image and copyright information in PMC

Comment on

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