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Comment
. 2022 Dec 6;34(12):1903-1905.
doi: 10.1016/j.cmet.2022.11.010.

Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade

Hassane M Zarour  1
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Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade

Hassane M Zarour. Cell Metab. .
Free article

Abstract

The tumor and gut microbiome regulate antitumor immunity and modulate responses to immune checkpoint blockade, although the mechanisms of action remain uncertain. A recent study in Science Immunology by Mirji et al. describes that the microbiota-generated metabolite trimethylamine N-oxide (TMAO) plays a critical role in mediating the effects of the microbiome on antitumor immunity.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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