Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 25;7(8):1351-1355.
doi: 10.1182/bloodadvances.2022007937.

Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience

Bahga Katamesh  1 , Ahmad Nanaa  1   2 , Rong He  3 , David Viswanatha  3 , Phuong Nguyen  3 , Patricia Greipp  3 , Kurt Bessonen  4 , Naseema Gangat  1 , Kebede Begna  1 , Abhishek Mangaonkar  1 , Mrinal Patnaik  1 , William J Hogan  1 , Ayalew Tefferi  1 , Mark Litzow  1 , Mithun Vinod Shah  1 , Cecilia Arana Yi  5 , James Foran  6 , Talha Badar  6 , Hassan B Alkhateeb  1 , Aref Al-Kali  1
Affiliations

Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience

Bahga Katamesh et al. Blood Adv. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
STAG2m characteristicsin patients with MN. (A) Representation of STAG2 variants detected, positioned on the STAG2 protein and its functional domains. The protein alterations are indicated on top of the corresponding mutation location, exon locations are indicated below the protein. (B) Comutational pattern in 91 patients with STAG2m MN. Each patient is represented by a column. The number reported in the box represents the VAF of each mutation. (C) OS for 88 patients with STAG2m MN. (D) OS for tMN vs dnMN in patients with STAG2m. STAG, STAG domain; aa, amino acid.
See this image and copyright information in PMC

References

    1. Hill VK, Kim JS, Waldman T. Cohesin mutations in human cancer. Biochim Biophys Acta. 2016;1866(1):1–11. - PMC - PubMed
    1. Jann JC, Tothova Z. Cohesin mutations in myeloid malignancies. Blood. 2021;138(8):649–661. - PMC - PubMed
    1. Viny AD, Levine RL. Cohesin mutations in myeloid malignancies made simple. Curr Opin Hematol. 2018;25(2):61–66. - PMC - PubMed
    1. Makishima H, Yoshizato T, Yoshida K, et al. Dynamics of clonal evolution in myelodysplastic syndromes. Nat Genet. 2017;49(2):204–212. - PMC - PubMed
    1. Thota S, Viny AD, Makishima H, et al. Genetic alterations of the cohesin complex genes in myeloid malignancies. Blood. 2014;124(11):1790–1798. - PMC - PubMed