Maternal probiotic intake attenuates ileal Crh receptor gene expression in maternally separated rat offspring

Abstract

Corticotropin-releasing hormone (Crh) and its receptors (Crhr) mediate stress-induced gastrointestinal dysfunctions. Neonatal maternal separation (MS) increased ileal Crhr1 transcript quantities in young rat offspring. Exposure to either MS or adulthood restraint stress increased ileal Crhr1 and Crhr2 transcript quantities only in adult female offspring. Maternal probiotic intervention reversed Crhr overexpression, suggesting a potential early prophylaxis against stress-induced gut dysfunctions.

Keywords: Ileum; corticotropin-releasing hormone receptor; neonatal maternal separation; probiotic.