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. 2022 Dec;34(6):431-441.
doi: 10.5021/ad.21.260.

Allergic Sensitization Pattern in the Korean Dermatologic Patients

Yujin Han  1 , Yu Ri Woo  1 , Hei Sung Kim  1   2 , Jeong Deuk Lee  1 , Sookhee Choi  3 , Jeesuk Yu  4 , Sang Hyun Cho  5
Affiliations

Allergic Sensitization Pattern in the Korean Dermatologic Patients

Yujin Han et al. Ann Dermatol. 2022 Dec.

Abstract

Background: Avoiding causative allergens is important for controlling the clinical course of allergic diseases. Allergen sensitization is influenced by many factors including the environment and lifestyle. The socioeconomic development, climate, and lifestyle changes have increased the prevalence of allergic diseases worldwide. However, there is little information about changes in the trend of the common allergens over time.

Objective: This study was aimed at identifying the trends of the common allergens in Korea over a 10-year period based on the results of the multiple allergosorbent test chemiluminescent assay (MAST-CLA).

Methods: We retrospectively reviewed the medical records of 5,760 patients aged ≥18 years who visited the Dermatology Department at a tertiary hospital over a period of 10 years. The serum total immunoglobulin (Ig) E and specific IgE levels to 41 allergens were determined using MAST-CLA, along with the clinical diagnosis, duration of illness, white blood cell count and eosinophil percentage.

Results: Dermatophagoides farinae, Dermatophagoides pteronyssinus, and house dust were the most prevalent allergens during the 10 years period, but the percentage of higher class responses has decreased in recent years. The number of patients sensitized to house dust (p<0.001), dogs (p=0.005), and cats (p<0.001) increased while that of patients sensitized to cockroaches (p<0.001) and storage mites (p<0.001) decreased over time. There were no significant changes in the total number of sensitizing allergens over time.

Conclusion: The common allergens have changed over time. Based on the findings of this study, physicians and patients should consider changing their strategies for disease prevention and management.

Keywords: Allergens; Allergy; Atopic dermatitis; Immunoglobulin E; Multiple allergosorbent test chemiluminescent assay; Time trend.

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Conflict of interest statement

The authors have nothing to disclose.

Figures

Fig. 1
Fig. 1. Annual change in rank of the 10 most common allergens.
Fig. 2
Fig. 2. Annual change in the positive response rates of the 10 most common allergens.
See this image and copyright information in PMC

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