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Review
. 2022 Nov 21:13:1037124.
doi: 10.3389/fimmu.2022.1037124. eCollection 2022.

Description of CRISPR-Cas9 development and its prospects in human papillomavirus-driven cancer treatment

Yuhao Wei  1   2 , Zhen Zhao  1   2 , Xuelei Ma  1
Affiliations
Review

Description of CRISPR-Cas9 development and its prospects in human papillomavirus-driven cancer treatment

Yuhao Wei et al. Front Immunol. .

Abstract

Human papillomaviruses (HPVs) have been recognized as the etiologic agents of various cancers and are called HPV-driven cancers. Concerning HPV-mediated carcinogenic action, gene therapy can cure cancer at the molecular level by means of the correction of specific genes or sites. CRISPR-Cas9, as a novel genetic editing technique, can correct errors in the genome and change the gene expression and function in cells efficiently, quickly, and with relative ease. Herein, we overviewed studies of CRISPR-mediated gene remedies for HPV-driven cancers and summarized the potential applications of CRISPR-Cas9 in gene therapy for cancer.

Keywords: cancer treatment; clustered regularly interspaced short palindromic repeat/CRISPR-associated nuclease 9; gene editing; human papillomavirus; tumor microenvironment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The main working procedure of CRISPR-Cas9.
Figure 2
Figure 2
The target genomes in the HPV and host cell.
Figure 3
Figure 3
The pathways of HPV for immune-evasion mechanisms.
See this image and copyright information in PMC

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