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Meta-Analysis
. 2022 Nov 21:13:1008820.
doi: 10.3389/fendo.2022.1008820. eCollection 2022.

The association between metabolic parameters and evening chronotype and social jetlag in non-shift workers: A meta-analysis

Rui Zhang  1 , Xiaoling Cai  1 , Chu Lin  1 , Wenjia Yang  1 , Fang Lv  1 , Jing Wu  1 , Linong Ji  1
Affiliations
Meta-Analysis

The association between metabolic parameters and evening chronotype and social jetlag in non-shift workers: A meta-analysis

Rui Zhang et al. Front Endocrinol (Lausanne). .

Abstract

Aims: The aim of the study was to evaluate the association between evening chronotype and social jetlag (SJL) with obesity, blood glucose and lipid levels in non-shift working adults.

Methods: The databases of MEDLINE, EMBASE and Cochrane Reviews were searched for studies analyzing the metabolic parameters among groups of different chronotypes or SJL until Feb 2022. Weighted mean difference (WMD) and 95% confidence intervals (CI) were used to analyze the association between these parameters and chronotypes or SJL.

Results: A total of 27 studies were included in this meta-analysis. Compared with morning chronotype, the participants with evening chronotype had higher body mass index (BMI) (WMD= 0.44 kg/m2, 95%CI, 0.30 to 0.57 kg/m2, p<0.001), higher fasting blood glucose level (WMD= 5.83mg/dl, 95%CI, 3.27to 8.38 mg/dl, p<0.001), higher total cholesterol level (WMD= 6.63mg/dl, 95%CI, 0.69 to 12.56 mg/dl, p=0.03), and lower high density lipoprotein cholesterol (HDL-C) level (WMD= -1.80mg/dl, 95%CI, -2.30 to -1.31 mg/dl, p<0.001). Compared with the participants with small SJL, the participants with large SJL had larger waist circumference (WMD= 0.80cm, 95%CI, 0.77 to 0.83cm, p<0.001).

Conclusions: Evening chronotype and SJL were associated with obesity and unfavorable metabolic parameters of glucose and lipid metabolism.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022303401.

Keywords: Lipid; chronotype (morningness-eveningness); circadian misalignment; glucose metabolism; obesity; social jetlag (SJL).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the selection of studies.
Figure 2
Figure 2
The association between chronotype and adiposity. (A) The association between chronotype and BMI in general population and in patients with chronic diseases. (B) The association between chronotype and waist circumference.
Figure 3
Figure 3
The association between chronotype and glycemic indicators. (A) The association between chronotype and fasting blood glucose. (B) The association between chronotype and HbA1c. (C) The association between chronotype and the prevalence of T2DM.
Figure 4
Figure 4
The association between chronotypes and lipids levels. (A) The association between chronotypes and total cholesterol. (B) The association between chronotypes and HDL-c. (C) The association between chronotypes and triglyceride.
Figure 5
Figure 5
The association between social jetlag and metabolic parameters. (A) The association between social jetlag and BMI. (B) The association between social jetlag and waist circumference. (C) The association between social jetlag and HbA1c. (D) The association between social jetlag and fasting blood glucose. (E) The association between social jetlag and HDL-c.
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References

    1. Adan A, Archer SN, Hidalgo MP, Di Milia L, Natale V, Randler C. Circadian typology: A comprehensive review. Chronobiol Int (2012) 29(9):1153–75. doi: 10.3109/07420528.2012.719971 - DOI - PubMed
    1. Wittmann M, Dinich J, Merrow M, Roenneberg T. Social jetlag: misalignment of biological and social time. Chronobiol Int (2006) 23(1-2):497–509. doi: 10.1080/07420520500545979 - DOI - PubMed
    1. Buxton OM, Cain SW, O'Connor SP, Porter JH, Duffy JF, Wang W, et al. . Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med (2012) 4(129):129ra43. doi: 10.1126/scitranslmed.3003200 - DOI - PMC - PubMed
    1. Patterson F, Malone SK, Grandner MA, Lozano A, Perkett M, Hanlon A. Interactive effects of sleep duration and morning/evening preference on cardiovascular risk factors. Eur J Public Health (2018) 28(1):155–61. doi: 10.1093/eurpub/ckx029 - DOI - PMC - PubMed
    1. Teixeira GP, Guimaraes KC, Soares A, Marqueze EC, Moreno CRC, Mota MC, et al. . Role of chronotype in dietary intake, meal timing, and obesity: a systematic review. Nutr Rev (2022). doi: 10.1093/nutrit/nuac044 - DOI - PubMed