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Review
. 2022 Nov 21:13:1018971.
doi: 10.3389/fphys.2022.1018971. eCollection 2022.

Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review

Bowen Xu  1   2 , Chunxiao Wang  2 , Hongping Chen  2   3 , Lihui Zhang  2   3 , Lei Gong  2 , Lin Zhong  2 , Jun Yang  2
Affiliations
Review

Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review

Bowen Xu et al. Front Physiol. .

Abstract

Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty, cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage and death. Mitsugumin 53 (MG53), also known as Trim72, is a conservative member of the TRIM family and is highly expressed in mouse skeletal and cardiac muscle, with minimal amounts in humans. MG53 has been proven to be involved in repairing cell membrane damage. It has a protective effect on I/R injury in multiple oxygen-dependent organs, such as the heart, brain, lung, kidney, and liver. Recombinant human MG53 also plays a unique role in I/R, sepsis, and other aspects, which is expected to provide new ideas for related treatment. This article briefly reviews the pathophysiology of I/R injury and how MG53 mitigates multi-organ I/R injury.

Keywords: MG53; ischemia/reperfusion injury (I/R injury); multiple organs; protective; review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
When the plasma membrane was damaged, MG53 sensed the oxidized extracellular environment, and by combining with phosphatidylserine, it adhered to the plasma membrane and intracellular vesicles, and finally gathered at the injury site to seal the damaged membrane.
FIGURE 2
FIGURE 2
MG53 protects multiple organs from ischemia-reperfusion injury through blood circulation.
See this image and copyright information in PMC

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