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Review
. 2022 Nov 21:13:1012241.
doi: 10.3389/fphys.2022.1012241. eCollection 2022.

Extracellular vesicles: A potential future strategy for dental and maxillofacial tissue repair and regeneration

Ziwei Liu  1   2   3 , Situo Wang  1   2   3 , Na Huo  2 , Shuo Yang  2 , Quan Shi  2 , Juan Xu  2
Affiliations
Review

Extracellular vesicles: A potential future strategy for dental and maxillofacial tissue repair and regeneration

Ziwei Liu et al. Front Physiol. .

Abstract

Extracellular vesicles (EVs), nano-sized bilayer membrane structures containing lipids, proteins and nucleic acids, play key roles in intercellular communication. Compared to stem cells, EVs have lower tumorigenicity and immunogenicity, are easier to manage and cause fewer ethic problems. In recent years, EVs have emerged as a potential solution for tissue regeneration in stomatology through cell-free therapies. The present review focuses on the role of EVs in dental and maxillofacial tissue repair and regeneration, including in dental and periodontal tissue, maxilla and mandible bone, temporomandibular joint cartilage, peripheral nerve and soft tissue. We also make a brief overview on the mechanism of EVs performing functions. However, limitations and challenges in clinical application of EVs still exist and should be addressed in future researches.

Keywords: clinical application; dental and maxillofacial tissue repair; extracellular vesicles; regenerative medicine; therapeutic effects.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The application of EVs for dental and maxillofacial tissue repair and regeneration.
See this image and copyright information in PMC

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