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Review

Secreted Virulence Factors of Streptococcus pyogenes

Timothy Barnett  1   2 , Anuk Indraratna  3   4 , Martina Sanderson-Smith  3   4
Joseph J. Ferretti  1 , Dennis L. Stevens  2 , Vincent A. Fischetti  3
, editors.
In: Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. 2nd edition. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2022 Oct 8. Chapter 13.
[updated ].
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Review

Secreted Virulence Factors of Streptococcus pyogenes

Timothy Barnett et al.
Free Books & Documents

Excerpt

Streptococcus pyogenes strains produce a wide variety of secreted or released extracellular products, many of which are virulence factors due to their roles in promoting disease and/or survival of this pathogen in the host. This chapter reviews those virulence factors that are secreted and/or released from the bacterial surface, including: streptokinase, proteinases, esterase, the hemolysins SLO and SLS, CAMP factor, DNases, hyaluronidases, complement inhibitor, superoxide dismutase, M protein fragments, and immunoglobulin-degrading enzymes. Many of these virulence factors may also function as digestive enzymes that provide the bacteria with nutrients from the host.

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