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Review
. 2023 Feb;64(2):131-138.
doi: 10.1007/s00108-022-01444-3. Epub 2022 Dec 8.

[Parkinson's disease]

[Article in German]
Tobias Warnecke  1   2   3 , Carina Lummer  4 , Johannes Wilhelm Rey  5 , Inga Claus  6   7 , Dieter Lüttje  8   9
Affiliations
Review

[Parkinson's disease]

[Article in German]
Tobias Warnecke et al. Inn Med (Heidelb). 2023 Feb.

Abstract
in English, German

Parkinson's disease (PD) is an unparalleled example of a neurodegenerative disorder that can be effectively managed leading to sustained symptom control and quality of life. The cooperation of neurologists with general practitioners, gastroenterologists, and geriatricians is of increasing importance for an optimized management of PD. New diagnostic criteria for PD and for atypical Parkinsonism, which should be considered in the differential diagnostics, include non-motor symptoms and aim to diagnose these disorders as early as possible. Recent research has shown that there are highly complex and clinically relevant interactions with PD at all levels of the gastrointestinal tract, which have been increasingly better understood and have direct clinical relevance. Novel dopaminergic treatment approaches focus on circumvention of the impaired gastrointestinal tract of PD patients. The management of geriatric PD patients and PD dementia requires specific clinical knowledge. Worldwide, PD has emerged as a model disease for the development of network structures for the treatment of chronic neurological diseases.

Die Parkinson-Krankheit (PK) ist das eindrücklichste Beispiel für eine effektiv therapierbare neurodegenerative Erkrankung mit lang anhaltender stabiler Symptomkontrolle und Lebensqualität. Der Zusammenarbeit von Neurologen mit Hausärzten, Gastroenterologen und Geriatern kommt immer größere Bedeutung zu. Neue Diagnosekriterien für die PK, aber auch für differenzialdiagnostisch zu erwägende atypische Parkinson-Syndrome beziehen nichtmotorische Symptome ein und haben das Ziel der möglichst frühen Diagnosestellung. Auf allen Ebenen des Gastrointestinaltrakts bestehen hochkomplexe Interaktionen mit der PK, die in den letzten Jahren immer besser verstanden wurden und unmittelbare klinische Relevanz haben. Neue dopaminerge Therapieoptionen fokussieren auch auf eine Umgehung des gestörten Gastrointestinaltrakts. Das Management der PK bei geriatrischen Patienten sowie der Parkinson-Demenz erfordert spezifisches Wissen. Die PK ist weltweit eine Modellkrankheit für die Entwicklung von Netzwerkstrukturen zur Versorgung chronisch-neurologischer Erkrankungen.

Keywords: Dementia; Dysphagia; Geriatrics; Parkinson networks; Parkinsonian syndromes.

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References

Literatur

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