Editorial: the acid test-can bile acids predict recurrence of Clostridioides difficile infection? Authors' reply

Benjamin H Mullish^{1

2}, Laura Martinez-Gili^{1

3}, Jessica R Allegretti^{4

5}

Affiliations

¹ Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, London, UK.
² Departments of Gastroenterology and Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
³ Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
⁴ Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁵ Harvard Medical School, Boston, Massachusetts, USA.

Editorial

Benjamin H Mullish et al. Aliment Pharmacol Ther. 2023 Jan.

. 2023 Jan;57(1):169-170.

doi: 10.1111/apt.17303.

Benjamin H Mullish^{1

2}, Laura Martinez-Gili^{1

3}, Jessica R Allegretti^{4

5}

¹ Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital Campus, Imperial College London, London, UK.
² Departments of Gastroenterology and Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
³ Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
⁴ Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁵ Harvard Medical School, Boston, Massachusetts, USA.

No abstract available

Comment on

Assessing the clinical value of faecal bile acid profiling to predict recurrence in primary Clostridioides difficile infection.
Mullish BH, Martinez-Gili L, Chekmeneva E, Correia GDS, Lewis MR, Horneffer-Van Der Sluis V, Roberts LA, McDonald JAK, Pechlivanis A, Walters JRF, McClure EL, Marchesi JR, Allegretti JR. Mullish BH, et al. Aliment Pharmacol Ther. 2022 Dec;56(11-12):1556-1569. doi: 10.1111/apt.17247. Epub 2022 Oct 17. Aliment Pharmacol Ther. 2022. PMID: 36250604
Editorial: the acid test - can bile acids predict recurrence of Clostridioides difficile infection?
Lo SW, Segal JP. Lo SW, et al. Aliment Pharmacol Ther. 2023 Jan;57(1):167-168. doi: 10.1111/apt.17266. Epub 2022 Dec 5. Aliment Pharmacol Ther. 2023. PMID: 36468200 No abstract available.

1. Lo SW, Segal JP. Editorial: the acid test - can bile acids predict recurrence of Clostridioides difficile infection? Aliment Pharmacol Ther. 2022;57:167-168.
1. Mullish BH, Martinez-Gili L, Chekmeneva E, Correia GDS, Lewis MR, Horneffer-Van Der Sluis V, et al. Assessing the clinical value of faecal bile acid profiling to predict recurrence in primary Clostridioides difficile infection. Aliment Pharmacol Ther. 2022;56:1556-1569.
1. Mullish BH, Allegretti JR. The contribution of bile acid metabolism to the pathogenesis of Clostridioides difficile infection. Therap Adv Gastroenterol. 2021;28:14. https://doi.org/10.1177/17562848211017725/FORMAT/EPUB
1. Jones BV, Begley M, Hill C, Gahan CGM, Marchesi JR. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A. 2008;105:13580-5. https://doi.org/10.1073/pnas.0804437105
1. Kang JD, Myers CJ, Harris SC, Kakiyama G, Lee I-K, Yun B-S, et al. Bile acid 7α-dehydroxylating gut bacteria secrete antibiotics that inhibit Clostridium difficile: role of secondary bile acids. Cell Chem Biol. 2019;26:27-34.e4. https://doi.org/10.1016/J.CHEMBIOL.2018.10.003