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Comment
. 2023 Mar;33(3):197-198.
doi: 10.1038/s41422-022-00761-4.

Immune checkpoint inhibitors as senolytic agents

Parminder Singh  1 , Pankaj Kapahi  1 , Jan M van Deursen  2
Affiliations
Comment

Immune checkpoint inhibitors as senolytic agents

Parminder Singh et al. Cell Res. 2023 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1. Immune checkpoint activation in SNCs.
Stressed or damaged cells in a senescent state remain cell cycle arrested and produce a secretome enriched in immune modulatory factors that attract immune cells, including cytotoxic T cells that kill their target. Some SNCs escape clearance by inducing the checkpoint protein PD-L1, an event that involves autocrine SASP signaling, E2F transcriptional activity, and impaired proteasome activity. This rescue mechanism can be overcome by the administration of immune checkpoint inhibitors.
See this image and copyright information in PMC

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