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[Preprint]. 2022 Dec 4:2022.12.02.22283029.

doi: 10.1101/2022.12.02.22283029.

Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection?

Affiliations

¹ Division of General Internal Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
² Departments of Medicine, Epidemiology and Oncology, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
³ Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
⁴ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁵ Division of Endocrinology, Department of Medicine, University of North Carolina Medical School, Chapel Hill, NC.
⁶ University of Colorado Denver Anschutz Medical Campus, Denver, CO.
⁷ Institute for Health Informatics, University of Minnesota, Minneapolis, MN.
⁸ Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY.
⁹ Biostatistics Program, Office of the Director, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD.
¹⁰ Owl HealthWorks, Indianapolis, IN.

PMID: 36482974
PMCID: PMC9727757
DOI: 10.1101/2022.12.02.22283029

Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection?

Neha V Reddy et al. medRxiv. 2022.

[Preprint]. 2022 Dec 4:2022.12.02.22283029.

doi: 10.1101/2022.12.02.22283029.

Authors

Affiliations

¹ Division of General Internal Medicine, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN.
² Departments of Medicine, Epidemiology and Oncology, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
³ Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
⁴ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
⁵ Division of Endocrinology, Department of Medicine, University of North Carolina Medical School, Chapel Hill, NC.
⁶ University of Colorado Denver Anschutz Medical Campus, Denver, CO.
⁷ Institute for Health Informatics, University of Minnesota, Minneapolis, MN.
⁸ Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY.
⁹ Biostatistics Program, Office of the Director, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD.
¹⁰ Owl HealthWorks, Indianapolis, IN.

PMID: 36482974
PMCID: PMC9727757
DOI: 10.1101/2022.12.02.22283029

Update in

Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection? A population-level view in the EHR-based RECOVER program.
Reddy NV, Yeh HC, Tronieri JS, Stürmer T, Buse JB, Reusch JE, Johnson SG, Wong R, Moffitt R, Wilkins KJ, Harper J, Bramante CT; N3C and RECOVER Consortiums. Reddy NV, et al. J Clin Transl Sci. 2023 Mar 8;7(1):e90. doi: 10.1017/cts.2023.34. eCollection 2023. J Clin Transl Sci. 2023. PMID: 37125061 Free PMC article.

Abstract

Long-term sequelae of severe acute respiratory coronavirus-2 (SARS-CoV-2) infection may include an increased incidence of diabetes. Our objective was to describe the temporal relationship between new diagnoses of diabetes mellitus and SARS-CoV-2 infection in a nationally representative database. There appears to be a sharp increase in diabetes diagnoses in the 30 days surrounding SARS-CoV-2 infection, followed by a decrease in new diagnoses in the post-acute period, up to 360 days after infection. These results underscore the need for further investigation, as understanding the timing of new diabetes onset after COVID-19 has implications regarding potential etiology and screening and treatment strategies.

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Figures

Figure 1:. Among all persons with diabetes in the database, the proportion of diabetes cases that were diagnosed between Sept 2019 and February 2022, by 30-day periods relative to infection with SARS-CoV-2.
This plot represents the proportion of diabetes cases in the N3C database that were diagnosed after September 2019 in persons who did not have a previous diagnosis of diabetes. Each line represents a calendar month of the pandemic. The Y axis is the proportion of all persons with SARS-CoV-2 and a DM diagnosis who received the ICD code for DM after September 2019, and the temporal relationship between the diagnoses between 180 days prior to 360 days after the SARS-Co-V-2 infection. The large peak between 8 days before and 30 days after is represented in an inset so that the top of that peak is visible without compressing the Y axis.

Figure 2:. Number of new diabetes mellitus (DM) cases within 180 before and 360 days after SARS-CoV-2 infection, among individuals who have both EHR-recorded SARS-CoV-2 infection and ICD code for DM and did not have an ICD code for DM before September 2019.
Each line represents a calendar month during the pandemic; the Y axis is the number of new DM cases in the N3C database in persons with a documented SARS-CoV-2 infection. The x-axis is temporal relationship between the diabetes diagnosis relative to each individual’s SARS-CoV-2 infection.

See this image and copyright information in PMC

References

1. Apicella M, Campopiano MC, Mantuano M, Mazoni L, Coppelli A, Del Prato S. Covid-19 in people with DM: understanding the reasons for worse outcomes. Lancet DM Endocrinol. 2020; 8(9):782–792. doi: 10.1016/S2213-8587(20)30238-2. - DOI - PMC - PubMed
1. Corona G, Pizzocaro A, Vena W et al. DM is most important cause for mortality in Covid-19 hospitalized patients: Systematic review and meta-analysis. Rev Endocr Metab Disord. 2021; 22(2):275–296. doi: 10.1007/s11154-021-09630-8. - DOI - PMC - PubMed
1. Al-Aly Z, Xie Y, Bowe B. High-dimensional characterization of post-acute sequelae of Covid-19. Nature. 2021; 594(7862):259–264. doi: 10.1038/s41586-021-03553-9. - DOI - PubMed
1. Rubino F, Amiel SA, Zimmet P et al. New-Onset DM in Covid-19. N Engl J Med. 2020; 383(8):789–790. doi: 10.1056/NEJMc2018688. - DOI - PMC - PubMed
1. Xie Y, Al-Aly Z. Risks and burdens of incident DM in long Covid: a cohort study. Lancet DM Endocrinol. 2022; 10(5):311–321. doi: 10.1016/S2213-8587(22)00044-4. - DOI - PMC - PubMed

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This is a preprint.

Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection?

Affiliations

Are fewer cases of diabetes mellitus diagnosed in the months after SARS-CoV-2 infection?

Authors

Affiliations

Update in

Abstract

Figures

References

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