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Review
. 2022 Nov 22:12:1051282.
doi: 10.3389/fonc.2022.1051282. eCollection 2022.

The role of IL-35 and IL-37 in breast cancer - potential therapeutic targets for precision medicine

Yuntao Ma  1 , He Su  1 , Xuyun Wang  1 , Xiangdong Niu  1 , Yang Che  1 , Brett D Hambly  2 , Shisan Bao  1 , Xiaopeng Wang  1
Affiliations
Review

The role of IL-35 and IL-37 in breast cancer - potential therapeutic targets for precision medicine

Yuntao Ma et al. Front Oncol. .

Abstract

Breast cancer is still a major concern due to its relatively poor prognosis in women, although there are many approaches being developed for the management of breast cancer. Extensive studies demonstrate that the development of breast cancer is determined by pro versus anti tumorigenesis factors, which are closely related to host immunity. IL-35 and IL-37, anti-inflammatory cytokines, play an important role in the maintenance of immune homeostasis. The current review focuses on the correlation between clinical presentations and the expression of IL-35 and IL-37, as well as the potential underlying mechanism during the development of breast cancer in vitro and in vivo. IL-35 is inversely correlated the differentiation and prognosis in breast cancer patients; whereas IL-37 shows dual roles during the development of breast cancer, and may be breast cancer stage dependent. Such information might be useful for both basic scientists and medical practitioners in the management of breast cancer patients.

Keywords: IL-35; IL-37; anti-inflammatory; breast cancer; therapeutic targets.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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