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. 2022 Jun 15;2(1):e93.
doi: 10.1017/ash.2022.231. eCollection 2022.

Antibodies in healthcare personnel following severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection

Rachel E Bosserman  1 , Christopher W Farnsworth  2 , Caroline A O'Neil  1 , Candice Cass  1 , Daniel Park  1 , Claire Ballman  2 , Meghan A Wallace  2 , Emily Struttmann  1 , Henry Stewart  1 , Olivia Arter  1 , Kate Peacock  1 , Victoria J Fraser  1 , Philip J Budge  1 , Margaret A Olsen  1 , Carey-Ann D Burnham  2 , Hilary M Babcock  1 , Jennie H Kwon  1 ; CDC Prevention Epicenters
Affiliations

Antibodies in healthcare personnel following severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection

Rachel E Bosserman et al. Antimicrob Steward Healthc Epidemiol. .

Abstract

In a prospective cohort of healthcare personnel (HCP), we measured severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) nucleocapsid IgG antibodies after SARS-CoV-2 infection. Among 79 HCP, 68 (86%) were seropositive 14-28 days after their positive PCR test, and 54 (77%) of 70 were seropositive at the 70-180-day follow-up. Many seropositive HCP (95%) experienced an antibody decline by the second visit.

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Figures

Fig. 1.
Fig. 1.
IgG N-antibody signal at enrollment and follow-up. (A) Comparison of IgG N-antibody signal at the enrollment and follow-up visits. The median IgG N-antibody signal at the enrollment visit was 5.20 (IQR, 2.67–6.92) compared to the median IgG N-antibody signal at follow-up which was 2.79 (IQR, 1.44–5.21). IgG N-antibody signal was significantly decreased at the follow-up visit compared to the enrollment visit (Wilcoxon signed rank test P < .001). The solid diamonds represent the mean antibody signal at enrollment and follow-up, 4.84 and 3.20 index specimen/calibrator, respectively. (B) IgG N-antibody signals over time for each participant with antibody test results from both study visits (n = 70). The dotted line represents the seropositivity threshold.
See this image and copyright information in PMC

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