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. 2023 Mar;67(3):228-238.
doi: 10.1111/jir.12997. Epub 2022 Dec 9.

Early developmental profiles among infants with Down syndrome

S Onnivello  1 , E K Schworer  2 , M A Prince  3 , L A Daunhauer  4 , D J Fidler  4
Affiliations

Early developmental profiles among infants with Down syndrome

S Onnivello et al. J Intellect Disabil Res. 2023 Mar.

Abstract

Background: Down syndrome (DS) generally predisposes children to a pattern of relative developmental strengths and challenges, but within-syndrome heterogeneity is also commonly observed across many dimensions. The present research examines whether heterogeneity in developmental presentation can be detected during infancy in DS and whether factors associated with differing profiles can be identified.

Methods: Infants with DS (n = 75; age range: 3.9-17.6 months) were administered the Bayley Scales of Infant Development III (Bayley-III). A primary caregiver provided information regarding developmental history and family demographics. Latent profile analysis was conducted to identify whether early profiles were present across the five Bayley-III domains.

Results: Three developmental profiles were observable within the sample: a 'Mild Delay' Profile, an 'Moderate Delay' Profile and a 'Pronounced Delay' Profile. In addition, chronological age, having received heart surgery and having received occupational therapy were associated with probability of profile membership.

Conclusions: Findings from this study contribute to the growing knowledgebase regarding heterogenous presentations associated with DS and can inform early intervention planning.

Keywords: Down syndrome; developmental profiles; heterogeneity.

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References

    1. Abbeduto L., Warren S. F. & Conners F. A. (2007) Language development in Down syndrome: From the prelinguistic period to the acquisition of literacy. Mental Retardation and Developmental Disabilities Research Reviews 13, 247-261.
    1. Annaz D., Karmiloff-Smith A., Johnson M. H. & Thomas M. S. (2009) A cross-syndrome study of the development of holistic face recognition in children with autism, Down syndrome, and Williams syndrome. Journal of Experimental Child Psychology 102, 456-486.
    1. Aoki S., Yamauchi Y. & Hashimoto K. (2018) Developmental trend of children with Down's syndrome: how do sex and neonatal conditions influence their developmental patterns? Brain and Development 40, 181-187.
    1. Asparouhov T. & Muthén B. (2014) Auxiliary variables in mixture modeling: Three-step approaches using M plus. Structural Equation Modeling: A Multidisciplinary Journal 21, 329-341.
    1. Bakk Z. & Vermunt J. K. (2016) Robustness of stepwise latent class modeling with continuous distal outcomes. Structural Equation Modeling: A Multidisciplinary Journal 23, 20-31.

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