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. 2022 Dec 9;2022(1):408-413.
doi: 10.1182/hematology.2022000378.

Evidence-based management of pregnant women with sickle cell disease in high-income countries

Eugene Oteng-Ntim  1   2 , Panicos Shangaris  1   2   3
Affiliations

Evidence-based management of pregnant women with sickle cell disease in high-income countries

Eugene Oteng-Ntim et al. Hematology Am Soc Hematol Educ Program. .

Abstract

Globally, patients living with sickle cell disease are now surviving to reproductive age, with life expectancy approaching 50 years in most countries. Thus, reproductive options are now essential for patients living with the condition. However, it can be associated with maternal, delivery, and fetal complications. Outcomes may vary depending on the level of expertise and resources. In this piece we provide an optional guideline for managing sickle cell disease in pregnancy. The therapeutic option of serial exchange prophylactic transfusion has been offered in the context of a clinical trial (TAPS2).

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Conflict of interest statement

Eugene Oteng-Ntim: no competing financial interests to declare.

Panicos Shangaris: no competing financial interests to declare.

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References

    1. Oteng-Ntim E, Pavord S, Howard R, et al; British Society for Haematology Guideline. Management of sickle cell disease in pregnancy. A British Society for Haematology Guideline. Br J Haematol. 2021;194(6):980-995. doi:10.1111/bjh.17671. - DOI - PubMed
    1. Royal College of Obstetricians and Gynaecologists. Management of sickle cell disease in pregnancy. Accessed 8 September 2022. https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guideline....
    1. Piel FB, Patil AP, Howes RE, et al.. Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates. Lancet. 2013;381(9861):142-151. doi:10.1016/S0140-6736(12)61229-X. - DOI - PMC - PubMed
    1. Oteng-Ntim E, Ayensah B, Knight M, Howard J. Pregnancy outcome in patients with sickle cell disease in the UK—a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease. Br J Haematol. 2015;169(1):129-137. doi:10.1111/bjh.13270. - DOI - PubMed
    1. Oteng-Ntim E, Meeks D, Seed PT, et al.. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis. Blood. 2015;125(21):3316-3325. doi:10.1182/blood-2014-11-607317. - DOI - PubMed