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Comment
. 2023 Jan;44(1):4-6.
doi: 10.1016/j.it.2022.11.006. Epub 2022 Dec 6.

Subdoligranulum chews up joints: how a gut pathobiont can instigate arthritis

Martin A Kriegel  1
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Subdoligranulum chews up joints: how a gut pathobiont can instigate arthritis

Martin A Kriegel. Trends Immunol. 2023 Jan.

Abstract

The microbiota has been implicated in triggering certain autoimmune diseases. In rheumatoid arthritis (RA), the 'mucosal origins' hypothesis suggests that such a trigger can instigate systemic autoimmune responses that lead to synovial inflammation. Chriswell et al. recently identified a human gut commensal bound by monoclonal autoantibodies and eliciting autoantibody-mediated, transferable arthritis in gnotobiotic mouse models.

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Declaration of interests None declared by author.

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