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Comment
. 2022 Dec;23(12):1659-1661.
doi: 10.1038/s41590-022-01368-y.

Meningeal MAIT cells maintain meningeal and brain function

Robyn S Klein  1   2   3   4
Affiliations
Comment

Meningeal MAIT cells maintain meningeal and brain function

Robyn S Klein. Nat Immunol. 2022 Dec.

Abstract

Zhang et al. describe how meningeal MAIT cells maintain meningeal barrier integrity via the secretion of antioxidants, which also limit neuroinflammation and preserve spatial learning.

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Conflict of interest statement

Competing interests

The author declares no competing interests.

Figures

Fig. 1 |
Fig. 1 |. Loss of meningeal MAIT cells and downstream effects.
Skull bone of a wild-type mouse (bottom), with normal meningeal layers that exhibit the presence of MAIT cells and intact tight junctions (TJs) and adherens junctions (AJs); and meninges in an Mr1−/− mouse (top), with increased levels of ROS, loss of tight junction and adherens junction integrity, and activation of parenchymal microglia with associated cognitive disturbance.
See this image and copyright information in PMC

Comment on

References

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