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. 2023 Feb;33(2):2350008.
doi: 10.1142/S0129065723500089. Epub 2022 Dec 10.

Separating Inhibitory and Excitatory Responses of Epileptic Brain to Single-Pulse Electrical Stimulation

Sepehr Shirani  1 , Antonio Valentin  2 , Gonzalo Alarcon  3 , Farhana Kazi  2 , Saeid Sanei  1
Affiliations

Separating Inhibitory and Excitatory Responses of Epileptic Brain to Single-Pulse Electrical Stimulation

Sepehr Shirani et al. Int J Neural Syst. 2023 Feb.

Abstract

To enable an accurate recognition of neuronal excitability in an epileptic brain for modeling or localization of epileptic zone, here the brain response to single-pulse electrical stimulation (SPES) has been decomposed into its constituent components using adaptive singular spectrum analysis (SSA). Given the response at neuronal level, these components are expected to be the inhibitory and excitatory components. The prime objective is to thoroughly investigate the nature of delayed responses (elicited between 100[Formula: see text]ms-1 s after SPES) for localization of the epileptic zone. SSA is a powerful subspace signal analysis method for separation of single channel signals into their constituent uncorrelated components. The consistency in the results for both early and delayed brain responses verifies the usability of the approach.

Keywords: Delayed response; EEG; SPES; SSA; early response; epilepsy; excitation; inhibition.

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