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. 2023 Mar;37(3):e14883.
doi: 10.1111/ctr.14883. Epub 2022 Dec 20.

COVID-19-associated acute cellular rejection of a transplanted heart

Affiliations

COVID-19-associated acute cellular rejection of a transplanted heart

Crystal Lihong Yan et al. Clin Transplant. 2023 Mar.
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest related to this work.

Figures

FIGURE 1
FIGURE 1
AlloMap, Allosure, and rejection levels of our patient over time. In patients ≥6 months post‐transplant, an Allomap score >34 is associated with a higher probability of acute rejection. However, the Allomap score must also be interpreted in relation to previous scores as a significant increase would also be considered a higher risk of rejection. For Allosure, >0.15% dd‐cfDNA is associated with a higher probability of acute rejection.
FIGURE 2
FIGURE 2
Hematoxylin and eosin stain at (A) 4× magnification of myocardial tissue showing >2 foci of lymphocytic infiltrate associated with myocyte damage (asterisk) and endocardial inflammatory infiltrates (arrow) (B) 40× magnification showing endocardial inflammatory infiltrates (C) 40× magnification showing myocyte injury.

References

    1. Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29(8):914‐956. - PubMed
    1. Cooper LT Jr. Myocarditis. N Engl J Med. 2009;360(15):1526‐1538. - PMC - PubMed
    1. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24(11):1710‐1720. - PubMed
    1. Tajbakhsh A, Gheibi Hayat SM, Taghizadeh H, et al. COVID‐19 and cardiac injury: clinical manifestations, biomarkers, mechanisms, diagnosis, treatment, and follow up. Expert Rev Anti Infect Ther. 2021;19(3):345‐357. - PubMed