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Editorial
. 2022 Nov 23;11(23):3732.
doi: 10.3390/cells11233732.

Molecular Mechanisms to Target Cellular Senescence in Aging and Disease

Serena Marcozzi  1   2 , Antonio Paolo Beltrami  3 , Marco Malavolta  1
Affiliations
Editorial

Molecular Mechanisms to Target Cellular Senescence in Aging and Disease

Serena Marcozzi et al. Cells. .

Abstract

Cellular senescence is a state of irreversible cell cycle arrest in response to several stressors, including DNA damage, increased cellular oxidative stress, telomere shortening, oncogene activation, and a deep epigenetic remodeling [...].

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Cartoon summarizing the hypothesized interventions aimed at eradicating the chronic accumulation of senescent cells: (a) interventions suggested to prevent chronic diseases and improve health in aging; (b) the “one-two punch” strategy combining senogenic and senolytic therapies for the treatment of cancer.
See this image and copyright information in PMC

References

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