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. 2022 Nov 25;19(23):15722.
doi: 10.3390/ijerph192315722.

Current Evidence on the Association of Micronutrient Malnutrition with Mild Cognitive Impairment, Frailty, and Cognitive Frailty among Older Adults: A Scoping Review

Norhayati Mustafa Khalid  1 , Hasnah Haron  1 , Suzana Shahar  1 , Michael Fenech  1   2
Affiliations

Current Evidence on the Association of Micronutrient Malnutrition with Mild Cognitive Impairment, Frailty, and Cognitive Frailty among Older Adults: A Scoping Review

Norhayati Mustafa Khalid et al. Int J Environ Res Public Health. .

Abstract

Micronutrient malnutrition is thought to play an important role in the cause of cognitive impairment and physical frailty. The purpose of this scoping review was to map current evidence on the association between micronutrient deficiency in blood and mild cognitive impairment, frailty, and cognitive frailty among older adults. The scoping review was conducted based on the 2005 methodological framework by Arksey and O'Malley. The search strategy for potential literature on micronutrient concentration in blood and cognitive frailty was retrieved based on the keywords using electronic databases (PubMed, Cochrane Library, Google Scholar, Ovid, and Science Direct) from January 2010 to December 2021. Gray literature was also included in the searches. A total of 4310 articles were retrieved and 43 articles were incorporated in the review. Findings revealed a trend of significant association between low levels of B vitamins (folate and vitamin B12), vitamin D, vitamin A, vitamin E, omega 3 fatty acid, and albumin, and high homocysteine levels in blood with an increased risk of mild cognitive impairment among older adults. The results also indicated that low vitamin D levels, albumin, and antioxidants (lutein and zeaxanthin) in blood were significantly associated with frailty among older adults, while β-cryptoxanthin and zeaxanthin in blood were inversely associated with the risk of cognitive frailty. Vitamin D and antioxidants seemed to be targeted nutrients for the prevention of cognitive frailty. In conclusion, a wide range of micronutrient deficiency was associated with either mild cognitive impairment or frailty; however, little evidence exists on the dual impairment, i.e., cognitive frailty. This scoping review can serve as preliminary evidence for the association between micronutrient deficiency in blood and mild cognitive impairment, frailty, and cognitive frailty among older adults and prove the relevancy of the topic for future systematic reviews.

Keywords: cognitive frailty; frailty; micronutrient; mild cognitive impairment; older adults; scoping review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram for the selection of related articles.
Figure 2
Figure 2
Summary of findings on the association between micronutrient malnutrition and mild cognitive impairment, frailty, and cognitive frailty involved in the elderly.
See this image and copyright information in PMC

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References

    1. Kelaiditi E., Cesari M., Canevelli M., Abellan van Kan G., Ousset P.-J., Gillette-Guyonnet S., Ritz P., Duveau F., Soto M.E., Provencher V., et al. Cognitive Frailty: Rational and Definition from an (I.A.N.A./I.A.G.G.) International Consensus Group. J. Nutr. Health Aging. 2013;17:726–734. doi: 10.1007/s12603-013-0367-2. - DOI - PubMed
    1. Feng L., Shwe M., Nyunt Z., Gao Q., Feng L. Cognitive Frailty and Adverse Health Outcomes: Findings From the Singapore Longitudinal Ageing Studies ( SLAS ) J. Am. Med. Dir. Assoc. 2017;18:252–258. doi: 10.1016/j.jamda.2016.09.015. - DOI - PubMed
    1. Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., Seeman T., Tracy R., Kop W.J., Burke G., et al. Frailty in Older Adults: Evidence for a Phenotype. J. Gerontol.-Ser. A Biol. Sci. Med. Sci. 2001;56:146–157. doi: 10.1093/gerona/56.3.M146. - DOI - PubMed
    1. Gauthier S., Reisberg B., Zaudig M., Petersen R.C., Ritchie K., Broich K., Belleville S., Brodaty H., Bennett D., Chertkow H., et al. Mild Cognitive Impairment. Lancet. 2006;367:1262–1270. doi: 10.1016/S0140-6736(06)68542-5. - DOI - PubMed
    1. Feng L., Nyunt M.S.Z., Gao Q., Feng L., Lee T.S., Tsoi T., Chong M.S., Lim W.S., Collinson S., Yap P., et al. Physical Frailty, Cognitive Impairment, and the Risk of Neurocognitive Disorder in the Singapore Longitudinal Ageing Studies. J. Gerontol.-Ser. A Biol. Sci. Med. Sci. 2017;72:369–375. doi: 10.1093/gerona/glw050. - DOI - PubMed

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