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. 2022 Dec 3;23(23):15244.
doi: 10.3390/ijms232315244.

Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis

Elena García-Martín  1 , José A G Agúndez  1 , Javier Gómez-Tabales  1 , Julián Benito-León  2   3 , Jorge Millán-Pascual  4 , María Díaz-Sánchez  3 , Patricia Calleja  3 , Laura Turpín-Fenoll  4 , Hortensia Alonso-Navarro  5 , Esteban García-Albea  6 , José Francisco Plaza-Nieto  5 , Felix Javier Jiménez-Jiménez  5   6
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Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis

Elena García-Martín et al. Int J Mol Sci. .

Abstract

Several recent works have raised the possibility of the contribution of the lymphocyte activation gene 3 (LAG3) protein in the inflammatory processes of multiple sclerosis (MS). Results of studies on the possible association between LAG3 gene variants and the risk of MS have been inconclusive. In this study, we tried to show the possible association between the most common single nucleotide variants (SNVs) in the CD4 and LAG3 genes (these two genes are closely related) and the risk of MS in the Caucasian Spanish population. We studied the genotypes and allelic variants CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 in 300 patients diagnosed with MS and 400 healthy patients using specific TaqMan-based qPCR assays. We analyzed the possible influence of the genotype frequency on age at the onset of MS, the severity of MS, clinical evolutive subtypes of MS, and the HLADRB1*1501 genotype. The frequencies of the CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 genotypes and allelic variants were not associated with the risk of MS and were unrelated to gender, age at onset and severity of MS, the clinical subtype of MS, and HLADRB1*1501 genotype. The results of the current study showed a lack of association between the CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 SNVs and the risk of developing MS in the Caucasian Spanish population.

Keywords: CD4 gene; LAG3 gene; genetic polymorphisms; genetics; multiple sclerosis; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

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