Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 23;14(23):4979.
doi: 10.3390/nu14234979.

Gut Microbiota Profile in Adults Undergoing Bariatric Surgery: A Systematic Review

Vívian O R Coimbra  1 , Louise Crovesy  1 , Marcelo Ribeiro-Alves  2 , Ana Luísa K Faller  3 , Fernanda Mattos  1 , Eliane L Rosado  1
Affiliations

Gut Microbiota Profile in Adults Undergoing Bariatric Surgery: A Systematic Review

Vívian O R Coimbra et al. Nutrients. .

Abstract

Gut microbiota (GM) after bariatric surgery (BS) has been considered as a factor associated with metabolic improvements and weight loss. In this systematic review, we evaluate changes in the GM, characterized by 16S rRNA and metagenomics techniques, in obese adults who received BS. The PubMed, Scopus, Web of Science, and LILACS databases were searched. Two independent reviewers analyzed articles published in the last ten years, using Rayyan QCRI. The initial search resulted in 1275 documents, and 18 clinical trials were included after the exclusion criteria were applied. The predominance of intestinal bacteria phyla varied among studies; however, most of them reported a greater amount of Bacteroidetes (B), Proteobacteria (P), and diversity (D) after BS. Firmicutes (F), B, and the (F/B) ratio was inconsistent, increasing or decreasing after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) were conducted, compared to before surgery. There was a reduction in the relative proportion of F. Moreover, a higher proportion of Actinobacteria (A) was observed after RYGB was conducted. However, the same was not identified when SG procedures were applied. Genera abundance and bacteria predominance varied according to the surgical procedure, with limited data regarding the impact on phyla. The present study was approved by PROSPERO, under registration number CRD42020209509.

Keywords: bariatric surgery; gut microbiota; obesity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study.
See this image and copyright information in PMC

References

    1. WHO World Health Statistics 2016: Monitoring Health for the SDGs 2016. [(accessed on 1 June 2021)]. Available online: https://reliefweb.int/report/world/world-health-statistics-2016-monitori....
    1. ABESO Diretrizes Brasileiras de Obesidade 2016. [(accessed on 1 March 2021)]. Available online: https://abeso.org.br/wp-content/uploads/2019/12/Diretrizes-Download-Dire....
    1. Zhou H., Urso C.J., Jadeja V. Saturated Fatty Acids in Obesity-Associated Inflammation. J. Inflamm. Res. 2020;13:1–14. doi: 10.2147/JIR.S229691. - DOI - PMC - PubMed
    1. Backhed F., Ding H., Wang T., Hooper L.V., Koh G.Y., Nagy A., Semenkovich C.F., Gordon J.I. The Gut Microbiota as an Environmental Factor That Regulates Fat Storage. Proc. Natl. Acad. Sci. USA. 2004;101:15718–15723. doi: 10.1073/pnas.0407076101. - DOI - PMC - PubMed
    1. Medina D.A., Pedreros J.P., Turiel D., Quezada N., Pimentel F., Escalona A., Garrido D. Distinct Patterns in the Gut Microbiota after Surgical or Medical Therapy in Obese Patients. PeerJ. 2017;5:e3443. doi: 10.7717/peerj.3443. - DOI - PMC - PubMed

Publication types

Substances