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Review
. 2024 Dec;125(12):e30351.
doi: 10.1002/jcb.30351. Epub 2022 Dec 11.

FK506 binding protein 51: Its role in the adipose organ and beyond

Natalia M Galigniana  1   2 , Marina C Ruiz  1 , Graciela Piwien-Pilipuk  1
Affiliations
Review

FK506 binding protein 51: Its role in the adipose organ and beyond

Natalia M Galigniana et al. J Cell Biochem. 2024 Dec.

Abstract

There is a great body of evidence that the adipose organ plays a central role in the control not only of energy balance, but importantly, in the maintenance of metabolic homeostasis. Interest in the study of different aspects of its physiology grew in the last decades due to the pandemic of obesity and the consequences of metabolic syndrome. It was not until recently that the first evidence for the role of the high molecular weight immunophilin FK506 binding protein (FKBP) 51 in the process of adipocyte differentiation have been described. Since then, many new facets have been discovered of this stress-responsive FKBP51 as a central node for precise coordination of many cell functions, as shown for nuclear steroid receptors, autophagy, signaling pathways as Akt, p38 MAPK, and GSK3, as well as for insulin signaling and the control of glucose homeostasis. Thus, the aim of this review is to integrate and discuss the recent advances in the understanding of the many roles of FKBP51 in the adipose organ.

Keywords: FKBP51; adipogenesis; adipose tissue; obesity.

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