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Observational Study
. 2022 Dec 12;15(1):367.
doi: 10.1186/s13104-022-06261-3.

Impact of blood perilipin A levels on obesity and metabolic health

Emmanuel K Ofori  1 , Bright Selorm Letsu  2 , Seth K Amponsah  3 , John Ahenkorah  4 , Sandra Crabbe  5 , Genevieve Kwao-Zigah  2 , Sylvester Y Oppong  6 , Patrick Diaba-Nuhoho  7 , Seth D Amanquah  2
Affiliations
Observational Study

Impact of blood perilipin A levels on obesity and metabolic health

Emmanuel K Ofori et al. BMC Res Notes. .

Abstract

Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health.

Results: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = - 0.32, - 0.37, - 0.40, - 0.45, - 0.33 and - 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35-11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.

Keywords: Insulin resistance; Lipids; Obesity; Perilipin A.

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Conflict of interest statement

The authors disclose that they have no competing financial interests.

Figures

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Fig. 1
shows participant inclusion and study procedure
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