Gutsy sensations modulate intestinal disease

Wang Cao¹, Gabrielle Belz²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia.
² The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia; The University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address: g.belz@uq.edu.au.

PMID: 36503685
DOI: 10.1016/j.it.2022.11.007

Comment

Gutsy sensations modulate intestinal disease

Wang Cao et al. Trends Immunol. 2023 Jan.

. 2023 Jan;44(1):1-3.

doi: 10.1016/j.it.2022.11.007. Epub 2022 Dec 8.

Authors

Wang Cao¹, Gabrielle Belz²

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia.
² The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010, Australia; The University of Queensland Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia. Electronic address: g.belz@uq.edu.au.

PMID: 36503685
DOI: 10.1016/j.it.2022.11.007

Abstract

Pain is a hallmark symptom associated with intestinal inflammation. Two related articles published in Cell by Zhang et al. and by Yang et al. now report how sensory neurons in the gut, the most heavily innervated organ in the human body, flag bacterial pathogens to shape the composition of the gut microbiome and to trigger immunoregulatory mechanisms.

Keywords: enteric nervous system; gastrointestinal immune response; gut immunology; mast cells; neuroimmunology.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.
Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Chu C, Zhou L, Putzel GG, Li TT, Jin WB, Zhou J; JRI Live Cell Bank; Hu H, Tsou AM, Guo CJ, Artis D. Zhang W, et al. Cell. 2022 Oct 27;185(22):4170-4189.e20. doi: 10.1016/j.cell.2022.09.008. Epub 2022 Oct 14. Cell. 2022. PMID: 36240781 Free PMC article.
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Yang D, et al. Cell. 2022 Oct 27;185(22):4190-4205.e25. doi: 10.1016/j.cell.2022.09.024. Epub 2022 Oct 14. Cell. 2022. PMID: 36243004 Free PMC article.

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Gutsy sensations modulate intestinal disease

Affiliations

Gutsy sensations modulate intestinal disease

Authors

Affiliations

Abstract

Conflict of interest statement

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