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Review
. 2023 Jan:181:103889.
doi: 10.1016/j.critrevonc.2022.103889. Epub 2022 Nov 26.

Granulosa cell tumors (GCTs) of the ovary: What is the role of radiotherapy?

Amelia Barcellini  1 , Giorgia Mangili  2 , Andrei Fodor  3 , Simona Secondino  4 , Flavia Zerbetto  3 , Alexandra Charalampopoulou  5 , Sandro Pignata  6 , Ester Orlandi  7 , Alice Bergamini  2
Affiliations
Review

Granulosa cell tumors (GCTs) of the ovary: What is the role of radiotherapy?

Amelia Barcellini et al. Crit Rev Oncol Hematol. 2023 Jan.

Abstract

Granulosa cell tumors of the ovary have an indolent behavior and a good prognosis, but a high incidence of local recurrence after surgery. The best treatment in the recurrent setting is unclear and randomized clinical trials on the management in the recurrent setting are lacking. The role of radiotherapy is controversial in adjuvant settings and unknown in case of relapse after surgery. This review aims to summarize the level of evidence of the role of radiation treatments for granulosa cell tumors of the ovary.

Keywords: Granulosa cell tumor; Radiotherapy; Rare tumors; Sex cord-stromal tumor.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no competing interests.

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