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Meta-Analysis
. 2023 May;52(5):357-364.
doi: 10.1111/jop.13396. Epub 2023 Jan 13.

Association between autoimmune rheumatic diseases and head and neck cancer: Systematic review and meta-analysis

Nancy Vanessa Rodrigues Batista  1 , Remberto Marcelo Argandoña Valdez  1 , Elma Mariana Verçosa de Melo Silva  1 , Thayanara Silva Melo  1 , José Ricardo Dias Pereira  1 , Saman Warnakulasuriya  2 , Alan Roger Santos-Silva  3 , Angela Luzia Branco Pinto Duarte  4 , Henrique de Ataíde Mariz  4 , Luiz Alcino Gueiros  1
Affiliations
Meta-Analysis

Association between autoimmune rheumatic diseases and head and neck cancer: Systematic review and meta-analysis

Nancy Vanessa Rodrigues Batista et al. J Oral Pathol Med. 2023 May.

Abstract

Background: Personal history of autoimmune rheumatic diseases has been implicated in the development of malignant neoplasms. Our aim was to assess the risk of head and neck (H&N) cancers in patients with autoimmune rheumatic diseases.

Methods: The articles search included PubMed, EMBASE, LILACS, The Cochrane Library, CINAHL, Scopus, Web of Science, and Google Scholar with no language restrictions for studies published from inception of the databases to August 20, 2022, assessing the risk of H&N cancer in patients with autoimmune rheumatic diseases. Studies were included if they reported the standardized incidence ratio (SIR) with corresponding 95% confidence intervals (CIs). The primary outcome was risk of H&N cancers in patients with autoimmune rheumatic diseases compared with the general population. Pooled summary estimates were calculated using a random-effects model, and subgroup analyses were done to establish whether risk of H&N cancers varied according to study site.

Results: Our search identified 5378 records, of which 32 cohort studies were eligible for systematic review and 24 for meta-analysis (including 273 613 patients). A significant association was found between H&N cancer and autoimmune rheumatic diseases (SIR = 2.35; 95% CI: 1.57-3.50; p < 0.01, I2 = 94%).

Conclusion: Our study suggests that patients with autoimmune rheumatic diseases had a significantly increased risk of H&N cancer compared with the general population, including thyroid, oral, and nasopharyngeal cancers. These findings have implications for the individualized screening of these patients and the planning of oncology units. The protocol is registered with PROSPERO, number CRD42020197827.

Keywords: autoimmune diseases; head and neck neoplasms; meta-analysis; rheumatic diseases; systematic review.

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References

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