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. 2022 Dec 5:15:2759-2766.
doi: 10.2147/JMDH.S384386. eCollection 2022.

Acute Kidney Injury Among Patients with Multi-Drug Resistant Infection: A Study from Jordan

Ashraf O Oweis  1 , Heba N Zeyad  1 , Sameeha A Alshelleh  2 , Karem H Alzoubi  3   4
Affiliations

Acute Kidney Injury Among Patients with Multi-Drug Resistant Infection: A Study from Jordan

Ashraf O Oweis et al. J Multidiscip Healthc. .

Abstract

Background: Acute kidney injury (AKI) is a well-known complication for hospitalized patients. Sepsis and various infections play a significant role in increasing the incidence of AKI. The present study evaluated the risk for Multidrug-resistant (MDR) infections and its effect on the incidence of AKI, hospitalization, need for dialysis, and mortality.

Methods: In a retrospective study design, data were collected from all adult patients with a positive multi-drug resistant culture who were admitted to King Abdullah University Hospital (KAUH). Records of 436 patients were reviewed between January 2017 - December 2018 with at least one year of follow-up.

Results: The mean age was 57.3 years (SD± 23.1), and 58.5% were males. The most common source of positive cultures was sputum, with 50% positive cultures. The incidence of AKI was 59.2%. The most isolated microorganism was Acinetobacter baumannii (76.8%), followed by Pseudomonas aeruginosa (14.9%).On multivariate analysis, age (OR 1.1, 95% CI 1.1-1.2, P=0.001), HTN (OR 1.8, 95% CI 1.0-3.3, P=0.02), DM (OR 1.1, 95% CI 0.6-1.9, P=0.69) and the use of Foley catheter on chronic bases (OR 4.3, 95% CI 2.6-6.8, P<0.0001) were strong predictors of AKI. Among patients with AKI, 74.4% died compared to 44.4% among non-AKI patients (p<0.001).

Conclusion: In patients with MDR, AKI incidence, hospitalization, and mortality were high. Early detection and addressing the problem may decrease bad outcomes, and health education for reducing antibiotic abuse is needed to lower MDR.

Keywords: acute kidney injury; infection; mortality; multi-drug resistant.

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Conflict of interest statement

The authors report no competing interests in this work.

Figures

Figure 1
Figure 1
Acute kidney injury (AKI) stage based on Acute Kidney Injury Network (AKIN) classification.
Figure 2
Figure 2
eGFR based on AKI status on admission and at the last follow-up time.
Figure 3
Figure 3
Pie chart showing isolated microorganisms based on AKI status.
Figure 4
Figure 4
KM survival curve based on AKI status.
See this image and copyright information in PMC

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